Anaphylactoid reactions might occur (avoid use in patients who experience bronchospasm, asthma, rhinitis, or urticaria with NSAID or aspirin therapy). Increased risk of adverse cardiovascular thrombotic events, including MI, stroke, and new onset or worsening of pre-existing hypertension (use caution with fluid retention, heart failure, or hypertension). Increased risk of GI events (use caution with history of GI disease (bleeding or ulcers), concurrent therapy with aspirin, anticoagulants and/or corticosteroids, smoking, use of alcohol, elderly or debilitated patients). Skin reactions (including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis) might occur. Severe bronchospasm may occur (do not administer in aspirin-sensitive asthma, and use caution in other forms of asthma). Serious GI toxicity (e.g. bleeding, ulceration, perforation) can occur. Use contraindicated for treatment of perioperative pain in setting of CABG surgery. Risk of MI and stroke may be increased with use following CABG surgery. Severe hepatic reactions (e.g. fulminant hepatitis, liver failure) have occurred with NSAID use, rarely (use with caution in decreased hepatic function). Elevations of serum ALT or AST reported. Anemia reported rarely. May inhibit platelet aggregation and prolong bleeding time. May mask certain signs of infection. NSAID use may cause renal decompensation (not recommended for use in advanced renal disease). Long-term NSAID use may result in renal papillary necrosis. Use with caution in the elderly (increased risk for adverse effects). Withhold for at least 4-6 half-lives prior to surgical or dental procedures.