Ibutilide
- Atc Codes:C01BD05
- CAS Codes:122647-32-9#122647-31-8
- PHARMGKB ID:122647-32-9#122647-31-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Corvert; Finland: Corvert; Greece: Corvert; Italy: Corvert; Netherlands: Corvert; Sweden: Corvert.
North America
Canada: Corvert; USA: Corvert.
Drug combinations
Chemistry
Ibutilide Fumarate: (C~20~H~36~N~2~O~3~S)~2~ C~4~H~4~O~4~. Mw: 885.23. (1) Methanesulfonamide, N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-, (±)-, (E)-2-butenedioate (2:1); (2)(±)-4′-[4-(Ethylheptylamino)-1-hydroxybutyl]methanesulfonanilide fumarate (2:1). CAS-122647-32-9; CAS-122647-31-8 (ibutilide)(1990).
Pharmacologic Category
Class III Antiarrhythmics. (ATC-Code: C01BD05).
Mechanism of action
Prolongs action potential duration and effective refractory period in both atrial and ventricular cardiac tissue. Delays repolarization by activating a slow, predominantly sodium, inward current. Produces dose-related prolongation of QT interval, thought to be associated with antiarrhythmic activity. Negligible effects on heart rate, cardiac contractility, or blood pressure. Lacks β-adrenergic-blocking activity.
Therapeutic use
Used for rapid conversion of recent-onset atrial flutter or fibrillation to sinus rhythm.
Pregnancy and lactiation implications
Teratogenic and embryocidal in rats. Avoid use in pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to ibutilide or any component of the formulation. QTc >440 ms.
Warnings and precautions
Conduction disturbances (heart block) might occur. Potentially fatal arrhythmias (e.g. polymorphic ventricular tachycardia) can occur, usually in association with torsade de pointes (QT prolongation). Electrolyte imbalance (hypokalemia or hypomagnesemia) might occur. Avoid concurrent use with any drug that can prolong QT interval. Use with caution in the elderly.