Naphazoline
- Atc Codes:R01AA08#R01AB02#S01GA01
- CAS Codes:550-99-2#835-31-4
- PHARMGKB ID:550-99-2#835-31-4
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Special Considerations
Brand Names
Europe
Austria: Aconex, Coldan, Mertan, Rhinon, Rhinoperd; Belgium: Deltarhinol Mono, Naphcon, Neusinol, Priciasol, Vasocedine Naphazoline; Czech Republic: Sanorin; Estonia: Sanorin; Germany: Privin, Proculin, Rhinex Nasenspray mit Naphazolin, Sednesa, Tele-Stulln Mono UD; Greece: Coldan; Hungary: Naphazolin; Ireland: Albalon, Murine Irritation & Redness Relief; Italy: Collirio Alfa, Imidazyl Coll., Iridina Due, Nafaz N, Naftazolina, Rinazina; Latvia: Naphthyzinum, Sanorin; Lithuania: Sanorin; Luxembourg: Naphcon Forte; Malta: Murine, Rino-Naftazolina; Poland: Rhinazin; Romania: Nafa-Gal, Nafazoptin, Proculin, Rinofug, Sanorin; Slovakia: Sanorin; Slovenia: Benil; Spain: Colirio Alfa, Miraclar, Vasoconstrictor Pensa.
North America
Canada: AK CON, Albalon, Collyre Bleu Laiter, Diopticon Liq, Naphcon Forte; USA: Albalon, Nafazair.
Latin America
Argentina: Actifedrin Nasal, Afluhist, Bactio Rhin, Disel, Fabozolina, Gentisyl NF, Gotinal, Let-Nasal, Mirasan, Mirus-S, Nafazolex, Nasalex Forte, Panoptic NF, Privina, Rhinal; Brazil: Claroft, Nafazolina, Privina; Mexico: Afazol, Alfazina, Fazolin, Gamatropin, Gotinal, Nafazolina, Nazil Ofteno, Oftaseptik, Soltrictor con Lagrifilm.
Asia
Japan: Naphazoline, Privina.
Drug combinations
Naphazoline and Antazoline
Naphazoline and Cromolyn
Naphazoline and Dexamethasone
Naphazoline and Ephedrine
Naphazoline and Hydrocortisone
Naphazoline and Mepyramine
Naphazoline and Methylene Blue
Naphazoline and Neomycin
Naphazoline and Pheniramine
Naphazoline and Prednisolone
Naphazoline, Antipyrine, and Lidocaine
Naphazoline, Dexamethasone, and Neomycin
Naphazoline, Dexamethasone, and Tobramycin
Naphazoline, Diphenhydramine, and Phenylephrine
Naphazoline, Ephedrine, and Isoflupredone
Naphazoline, Ephedrine, and Prednisolone
Naphazoline, Framycetin, and Prednisolone
Naphazoline, Gramicin, and Neomycin
Naphazoline, Hydrocortisone, and Neomycin
Naphazoline, Neomycin, and Prednisolone
Naphazoline, Chlorpheniramine, Dexamethasone, and Neomycin
Naphazoline, Cromolyn, Hyaluronic Acid, and Potassium
Other Naphazoline combinations: Retinol (Vitamin A)
Chemistry
Naphazoline Hydrochloride: C~14~H~14~N~2~ HCl. Mw: 246.74. (1) 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, monohydrochloride; (2) 2-(1-Naphthylmethyl)-2-imidazoline monohydrochloride. CAS-550-99-2; CAS-835-31-4 (naphazoline).
Pharmacologic Category
EENT Preparations; Vasoconstrictors; α~1~-Adrenergic Agonist; Imidazoline Derivative. Ophthalmic Agent; Vasoconstrictor. (ATC-Code: R01AA08; R01AB02; S01GA01).
Mechanism of action
Stimulates α-adrenergic receptors in arterioles of conjunctiva and nasal mucosa to produce vasoconstriction.
Therapeutic use
Topical ocular vasoconstrictor. Temporary relief of nasal congestion associated with common cold, upper respiratory allergies or sinusitis. Relief of redness of eye due to minor irritation.
Pregnancy and lactiation implications
Naphazoline hydrochloride should be used during pregnancy only when clearly needed. Animal reproduction studies not conducted. Excretion in breast milk unknown (use caution).
Unlabeled use
Contraindications
Hypersensitivity to naphazoline or any component of the formulation. Angle-closure glaucoma.
Warnings and precautions
Rebound nasal congestion might occur with extended use. Use with caution in chronic asthma, hypertension, heart failure, coronary artery disease, cerebral arteriosclerosis, diabetes mellitus, hyperthyroidism, local infection or injury, and in benign prostatic hyperplasia. Avoid concurrent use with MAOIs (may cause hypertensive crisis). Not recommended for use in children <6 years of age. Excessive dosage may cause CNS depression in children, coma and marked reduction in body temperature. Ophthalmic products may contain benzalkonium chloride.