Sodium Acetate
- Atc Codes:B05XA08
- CAS Codes:6131-90-4#127-09-3
- PHARMGKB ID:6131-90-4#127-09-3
Table of contents
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Dosage
- Special Considerations
Brand Names
Drug combinations
Sodium Acetate: Acetylcysteine; Alanine; Aminoacetic Acid; Arginine; Arginine Glutamate; Aspartic Acid; Calcium Chloride; Calcium Citrate; D,L-Methionine; Fish oil rich in ω-3 Acids; Gluconate Sodium; Glucose; Glucose Monohydrate; Glutamic Acid; Glycine; Histidine; Histidine Hyprochloride Monohydrate; Hydroxyethyl Starch; Isoleucine; L-Lysine; Leucine; Magnesium Acetate Tetrahydrate; Magnesium Chloride Anhydrous; Magnesium Chloride Dihydrate; Magnesium Chloride Hexahydrate; Magnesium Sulfate; Magnesium Sulfate Heptahydrate; Malic Acid; Methionine; N-Acetyltyrosine; Olive Oil; Ornithine Hydrochloride; Phenylalanine; Poly (O-2-hydroxyethyl) Starch; Potassium Acetate; Potassium Chloride; Potassium Hydroxide; Potassium Phosphate Dibasic; Proline; Serine; Sodium Chloride; Sodium Dihydrogen Phosphate Dihydrate; Sodium Gluconate; Sodium Glycerophosphate; Sodium Hydroxide; Sodium Lactate; Sodium Phosphate Monobasic; Soybean Oil; Taurine; Threonine; Triglycerides; Tryptophan; Tyrosine; Valine; Zinc Sulfate
Chemistry
Sodium Acetate: C~2~H~3~NaO~2~ 3H~2~O. Mw: 136.08. Acetic acid, sodium salt, trihydrate. CAS-6131-90-4; CAS-127-09-3 (anhydrous).
Pharmacologic Category
Replacement Preparations; Electrolyte Solutions. Parenteral Electrolyte Supplement. (ATC-Code: B05XA08).
Mechanism of action
Sodium is the principal extracellular cation. Functions in fluid and electrolyte balance, osmotic pressure control, and water distribution. Acetate is metabolized to bicarbonate which neutralizes hydrogen ion concentration and raises blood and urinary pH.
Therapeutic use
Sodium source in large volume I.V. fluids to prevent or correct hyponatremia in restricted intake. To counter acidosis through conversion to bicarbonate.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Alkalosis, hypocalcemia, low sodium diets, edema, cirrhosis.
Warnings and precautions
Close monitoring of serum sodium concentrations is needed to avoid hypernatremia. Use with caution in acid/base alterations (contains acetate), in edematous patients, and in severe hepatic/renal impairment. Use extreme caution in heart failure. Solution for injection contains aluminum (caution if impaired renal function or premature infants). Avoid extravasation.