Amyl Nitrite
- Atc Codes:V03AB22
- CAS Codes:110-46-3#8017-89-8
- PHARMGKB ID:110-46-3#8017-89-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Substrate of
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Special Considerations
Brand Names
Europe
Czech Republic: Amyl Nitrite.
Drug combinations
Chemistry
Amyl Nitrite: C~5~H~11~NO~2~. Mw: 117.15. A mixture of nitrous acid, 2-methylbutyl ester, and nitrous acid, 3-methylbutyl ester. CAS-110-46-3; CAS-8017-89-8 (mixture).
Pharmacologic Category
Vasodilating Agents; Nitrates and Nitrites. Antidote. (ATC-Code: V03AB22).
Mechanism of action
Relaxes vascular smooth muscle. Decreases venous ratios and arterial blood pressure. Reduces left ventricular work. Decreases myocardial O~2~ consumption. In cyanide poisoning, amyl nitrite converts hemoglobin to methemoglobin that binds with cyanide to form cyanate hemoglobin.
Therapeutic use
Coronary vasodilator in angina pectoris. Adjunct in treatment of cyanide poisoning. Changes in intensity of heart murmurs. Recreational drug during intercourse.
Pregnancy and lactiation implications
Contraindicated during pregnancy. Not recommended during lactation.
Unlabeled use
Contraindications
Hypersensitivity to nitrates. Severe anemia. Head injury. Angle-closure glaucoma. Postural hypotension. Head trauma or cerebral hemorrhage. Pregnancy.
Warnings and precautions
Use with caution in coronary artery disease, in hypotension or in increased intracranial pressure.