Aspirin (Acetylsalicylic Acid)
- Atc Codes:A01AD05#B01AC06#N02BA01
- CAS Codes:50-78-2
- PHARMGKB ID:50-78-2
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Induces
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Acekapton, Aspiricor, Aspirin, Aspro, CorProtect, Herz ASS, Herzschutz ASS, Thrombo ASS, Thrombostad, Togal Mono, Tromalyt ASS Retard; Belgium: Acenterine, ASA, Asaflow, Aspegic, Aspirine, Cardegic, Cardioaspirine, Cardiphar, Dispril, Sedergine; Bulgaria: Acetylin, Acetysal, Anopyrin, Aspegic, Aspetin, Aspirin, Keptan, Thrombo ASS, Trombogard, Unirex; Cyprus: Aspirem, Aspirin, Aspro Clear, Disprin, Nu-Seals, Salospir; Czech Republic: Acylpyrin, Anopyrin, Aspirin, Godasal, Kardegic; Denmark: Aspirin, Hjerdyl, Hjertemagnyl, Magnyl; Estonia: Acidum Acetylsalicylicum, ASA, Aspirin, Asprovit, Herzass, Thrombo Ass; Finland: ASA, Aspirin, Disperin, Primaspan, Thrombo ASA; France: Acide Acetylsalicylique, Aspirine, Aspirisucre, Aspro; Germany: Acesal, Acetylsalicylsäure, Andolor N, Apernyl mit Acetylsalicylsäure, ASA Atid, Aspirin, Aspro, ASS, Avensis, Gepodan, Godamed, Hermasalin, Miniasal, Pyracyl N, Sanocapt, Sonopain, Thrombo-Solpyron, Usambramed N; Greece: Acetylsalicylic Acid, Asacard, Aspirin, Bufferin, Dispril, New Asper, Salospir; Hungary: ASA, Aspirin, Aspro C, Astrix, Kardegic; Ireland: Asacard, Aspirin, Caprin, Disprin, Nu-Seals; Italy: Ac Acsal, Aspirina, Aspirinetta, Aspro, Cardioaspirin; Latvia: Acetilsalicilskābe, Alka-Prim, ASA, Aspecardum, Aspirin, HerzASS, Thrombo ASS; Lithuania: Acetylsalicylic Acid; Malta: Aspegic, Aspirin, Aspro Clear, Maximum Strength, Nu-Seals; Netherlands: Acetylsalicylzuur, Asacard, Aspirine, Aspro, Togal; Poland: Acard, Acesan, Ampiryna, Anopyrin, ASA, Asaltec, Aspirin, Aspotabs, Aspro, Bestpirin, Cardiopirin, Encopirin, Entreik, Miraspryn, Nipas, Novasen, Novaspryn, Polocard, Polopiryna, Proficar, Rhonal, Salpirin, Tomapyrin Comfort, Upsarin; Portugal: A-A-S, Ácido Acetilsalicílico, Actipiril, Asacard, ASP, Aspirina, Cartia, Migraspirina, Toldex Retard, Tromalyt; Romania: Acesil, Acid Acetilsalicilic, Asaprin, Aspenter, Aspimax, Aspirin, Europirin, Ozopirin T, Rompirin E, Thrombo ASS; Slovakia: Acylpyrin, Anopyrin, Aspirin; Slovenia: Andol, Aspirin, Cardiopirin; Spain: A.A.S., Adiro, Aspirina, Bioplak, Rhonal, Sedergine, Tromalyt; Sweden: Acetylsalicylsyra, Acetyratio, Albyl Minor, Asacard, Aspirin, Bamyl, Magnecyl, Trombyl; UK: Aspirin, Caprin, Nu-Seals.
North America
Canada: Acetylsalicylic Acid, ASA, Asadol, Asaphen, Asatab, Aspergum, Aspirin, Bufferin, Entrophen, Lowprin, Novasen, Rivasa; USA: Ascriptin, Aspercin, Aspergum, Aspirin, Aspirtab, Bufferin, Buffinol, Easprin, Ecotrin, Genacote, Halfprin, Zorprin.
Latin America
Argentina: A.A.S., Aspirina, Aspirinetas, Bayaspirina, Cardioaspirina, Desenfriolito, Ecotrin, Geniol SC sin cafeina, Lafeaspirina, Nuevapina, Vipirina Ginsex Corazón; Brazil: A.A.S, Ácido Acetilsalicílico, Analgesin, Aspirina, Bufferin, Cardio AAS, Cimaas, Salicil, Salicin, Salitil, Somalgin;
Mexico: Acetil-A, Ácido Acetilsalicílico, Acitab, Antacsal, ASA, Aspirina Protect, Doloquim, Midolen, Vastecel.
Asia
Japan: Acetyl Salicylic Acid, Aspirin, Bayaspirin, Nichiaspirin, Salitison, Zenaspirin.
Drug combinations
Aspirin and Acetaminophen
Aspirin and Ascorbic Acid (Vitamin C)
Aspirin and Caffeine
Aspirin and Carisoprodol
Aspirin and Cilostazol
Aspirin and Clopidogrel
Aspirin and Codeine
Aspirin and Dipyridamole
Aspirin and Magnesium Oxide
Aspirin and Methocarbamol
Aspirin and Metoclopramide
Aspirin and Oxycodone
Aspirin and Pentazocine
Aspirin and Pravastatin
Aspirin, Acetaminophen, and Caffeine
Aspirin, Acetaminophen, and Codeine
Aspirin, Ascorbic Acid (Vitamin C), and Caffeine
Aspirin, Ascorbic Acid (Vitamin C), and Codeine
Aspirin, Ascorbic Acid (Vitamin C), and Troxerutin
Aspirin, Ascorbic Acid (Vitamin C), Tocopherol (Vitamin E)
Aspirin, Butalbital, and Caffeine
Aspirin, Caffeine, and Chlorpheniramine
Aspirin, Caffeine, and Dihydrocodeine
Aspirin, Caffeine, and Orphenadrine
Aspirin, Caffeine, and Quinine
Aspirin, Carisoprodol, and Codeine
Aspirin, Chlorpheniramine, and Phenylephrine
Aspirin, Diphenylpyraline, and Metamfepramone
Aspirin, Lithium, and Quinine
Aspirin, Ascorbic Acid (Vitamin C), Caffeine, and Guaifenesin
Aspirin, Acetaminophen, Aluminum Hydroxide, Caffeine, and Magnesium Hydroxide
Aspirin, Aluminum Hydroxide, Ascorbic Acid, Caffeine, Chlorpheniramine, and Magnesium Carbonate
Other Aspirin combinations: Sodium Bicarbonate
Chemistry
Aspirin: C~9~H~8~O~4~. Mw: 180.16. (1) Benzoic acid, 2-(acetyloxy)-; (2) Salicylic acid acetate. CAS-50-78-2.
Pharmacologic Category
Platelet-aggregation Inhibitors. Thrombolytic Agents. Nonsteroidal Anti-inflammatory Agents; Salicylates. (ATC-Code: A01AD05; B01AC06; N02BA01; N02BA01).
Mechanism of action
Inhibits prostaglandin synthesis. Acts on the hypothalamus heat-regulating center to reduce fever. Blocks prostaglandin synthetase action, which prevents formation of the platelet-aggregating substance thromboxane A~2.~
Therapeutic use
Treatment of pain, inflammation, fever. Prophylaxis of myocardial infarction, stroke or transient ischemic episodes. Rheumatoid arthritis, rheumatic fever, osteoarthritis, and gout, revascularization procedures (coronary artery bypass graft, percutaneous transluminal coronary angioplasty, carotid endarterectomy), stent implantation.
Pregnancy and lactiation implications
Salicylates cross the placenta and enter fetal circulation. In general, low doses during pregnancy needed for the treatment of certain medical conditions have not been shown to cause fetal harm, however, discontinuing therapy prior to delivery is recommended. Use of safer agents for routine management of pain or headache should be considered. Use with caution while breast-feeding.
Unlabeled use
Prevention of pre-eclampsia, complications associated with autoimmune disorders (lupus or antiphospholipid syndrome).
Contraindications
Hypersensitivity to salicylates, other NSAIDs, or any component of the formulation. Asthma. Rhinitis. Nasal polyps. Inherited or acquired bleeding disorders (including factor VII and factor IX deficiency). Avoid use in children (<16 years of age) for viral infections (chickenpox or flu symptoms), with or without fever, due to a potential association with Reye’s syndrome. Pregnancy (third trimester especially).
Warnings and precautions
Risk of salicylate sensitivity. Discontinue use if tinnitus or impaired hearing occurs. Use with caution in platelet and bleeding disorders, in dehydration, in erosive gastritis or peptic ulcer disease or in renal impairment. Avoid use in severe renal and hepatic impairment. Avoid ethanol (can increase bleeding risks). Children and teenagers who have or are recovering from chickenpox or flu-like symptoms should not use this product (risk of developing Reye’s syndrome). Should be avoided in surgical patients for 1-2 weeks prior to surgery (to reduce the risk of excessive bleeding).