Amphetamines may impair ability to engage in potentially hazardous activities. A rare, frequently fatal disease of the lungs, primary pulmonary hypertension, found to occur with increased frequency in patients receiving some anorexigens. Use of some anorexigens associated with development of valvular heart disease. Avoid stimulants in known serious structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, or other serious cardiac problems which could increase risk of sudden death that these conditions alone carry. Use with caution in diabetes mellitus (antidiabetic agent requirements may be altered), in hypertension and other cardiovascular conditions which might be exacerbated by increases in blood pressure or heart rate, in history of seizure disorders, and in Tourette’s syndrome (stimulants may unmask tics). Not recommended for use in patients who have used other anorectic agents within the past year. Prolonged use may lead to dependency.