Potassium Iodide
- Atc Codes:R05CA02
- CAS Codes:7681-11-0
- PHARMGKB ID:7681-11-0
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Special Considerations
Brand Names
Europe
Austria: Jodid, Kaliumjodid; Belgium: Iodid; Denmark: Kaliumjodid; Finland: Jodix; France: Iodure de Potassium; Germany: Jodetten, Jodgamma, Jodid, Kaliumiodid, Kalium Jodatum, Mono-Jod, Thyroprotect; Hungary: Jodid; Luxembourg: Jodid; Poland: Jodam, Jodid, Jodostin, Jodox, Tarjod; Spain: Babyodo, Yodafar; Sweden: Kaliumjodid.
North America
USA: Iosat, Sski, ThyroSafe, ThyroShield.
Latin America
Brazil: Glitosslab, Iodeto de Potássio, Iodetoss, Xarope.
Asia
Japan: Potassium Iodide.
Drug combinations
Potassium Iodide and Sodium Iodide
Potassium Iodide, Chlorpheniramine, Codeine, and Phenylephrine
Other Potassium Iodide combinations: Ferrous Fumarate; Ginseng
Chemistry
Potassium Iodide: KI. Mw: 166.00. CAS-7681-11-0.
Pharmacologic Category
Miscellaneous Antifungals. Expectorants. Antithyroid Agents. Antidotes. (ATC-Code: R05CA02).
Mechanism of action
Reduces viscosity of mucus by increasing respiratory tract secretions. Inhibits secretion of thyroid hormone. Following radioactive iodine exposure, potassium iodide blocks uptake of radioiodine by the thyroid, reducing the risk of thyroid cancer.
Therapeutic use
Expectorant for symptomatic treatment of chronic pulmonary diseases complicated by mucous. Reduction of thyroid vascularity prior to thyroidectomy and management of thyrotoxic crisis. Blocking thyroidal uptake of radioactive isotopes of iodine in radiation emergency or other exposure to radioactive iodine.
Pregnancy and lactiation implications
Iodide crosses placenta (may cause hypothyroidism and goiter in fetus/newborn). Use as expectorant during pregnancy contraindicated. Enters breast milk (use caution). May cause skin rash in nursing infants.
Unlabeled use
Lymphocutaneous and cutaneous sporotrichosis.
Contraindications
Hypersensitivity to iodine or any component of the formulation. Hyperkalemia. Pulmonary edema. Impaired renal function. Hyperthyroidism. Iodine-induced goiter. Dermatitis herpetiformis. Hypocomplementemic vasculitis.
Warnings and precautions
Prolonged use can lead to hypothyroidism. Can cause acne flare-ups and/or dermatitis. Use with caution in Addison’s disease, acute bronchitis, cardiac disease, myotonia congenita, or tuberculosis. May have exaggerated response in cystic fibrosis. Use with caution in history of thyroid disease. Use with caution in patients receiving concomitant medications or therapies which increase potassium (e.g. ACEI, potassium-sparing diuretics, potassium-containing salt substitutes).