Alclometasone
- Atc Codes:D07AB10#S01BA10
- CAS Codes:66734-13-2
- PHARMGKB ID:66734-13-2
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Special Considerations
Brand Names
Europe
Denmark: Legederm; Germany: Delonal; Greece: Lomesone; Ireland: Modrasone; Italy: Legederm; Netherlands: Aclosone; Poland: Afloderm; Portugal: Miloderme; Slovakia: Afloderm; Slovenia: Afloderm; UK: BP Eczema and Dermatitis, Modrasone.
North America
USA: Aclovate, Alclometasone Dipropionate.
Asia
Japan: Aclovate.
Drug combinations
Chemistry
Alclometasone Dipropionate: C~28~H~37~ClO~7~. Mw: 521. (1) [2-[(7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate; (2)(7α-chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate). CAS-66734-13-2.
Pharmacologic Category
Anti-Inflammatory Agents; Topical Corticosteroids. (ATC-Code: D07AB10; S01BA10).
Mechanism of action
Like other topical corticosteroids, alclometasone dipropionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of topical steroids is, in general, unclear. However, corticosteroids are thought to act by the induction of phospholipase A~2~ inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A~2~.
Therapeutic use
Treatment of inflammation of corticosteroid-responsive dermatosis (low potency topical corticosteroid).
Pregnancy and lactiation implications
Not recommended during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to alclometasone or any component of the formulation; viral, fungal, or tubercular skin lesions.
Warnings and precautions
Adverse systemic effects may occur when used on large areas of the body, denuded areas, for prolonged periods of time, with an occlusive dressing, and/or in infants or small children (not for use in children <1 year of age). Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. Manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on treatment. If irritation develops, treatment should be discontinued and appropriate therapy instituted. If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used.