Balsalazide
- Atc Codes:A07EC04
- CAS Codes:150399-21-6#80573-04-2
- PHARMGKB ID:150399-21-6#80573-04-2
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Colazide; Denmark: Premid; Italy: Balzide; Sweden: Colazid; UK: Colazide.
North America
USA: Balsalazide, Colazal.
Latin America
Argentina: Benoquín.
Drug combinations
Chemistry
Balsalazide Disodium: C~17~H~13~N~3~Na~2~O~6~ 2H~2~O. Mw: 437.31. (1) Benzoic acid, 5-[[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]azo]-2-hydroxy-, disodium salt, dihydrate, (E)-; (2)(E)-5-[[p-[(2-Carboxyethyl)carbamoyl]phenyl]azo]salicylic acid, disodium salt, dihydrate. CAS-150399-21-6; CAS-80573-04-2 (balsalazide)(1994).
Pharmacologic Category
Gastrointestinal Drugs; Anti-inflammatory Agents; 5-Aminosalicylic Acid Derivative. (ATC-Code: A07EC04).
Mechanism of action
Prodrug, converted in colon to 5-aminosalicylic acid (active). Blocks the production of arachidonic acid metabolites topically in the colon mucosa.
Therapeutic use
Treatment of active ulcerative colitis.
Pregnancy and lactiation implications
No studies available. Should be used during pregnancy only if clearly needed. Use with caution during lactation.
Unlabeled use
Contraindications
Hypersensitivity to balsalazide, metabolites to balsalazide, salicylates, or any component of the formulation.
Warnings and precautions
May exacerbate symptoms of ulcerative colitis. Caution in pyloric stenosis or renal impairment.