Meclizine (Meclozine)
- Atc Codes:R06AE05
- CAS Codes:31884-77-2#1104-22-9#569-65-3
- PHARMGKB ID:31884-77-2#1104-22-9#569-65-3
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Belgium: Agyrax, Postafene; Denmark: Postafen; Finland: Postafen; France: Agyrax; Greece: Emetostop; Ireland: Sea Legs; Netherlands: Suprimal; Portugal: Navicalm; Romania: Emetostop; Spain: Chiclida, Dramine, Navicalm; Sweden: Postafen; UK: Sea-Legs.
North America
Canada: Bonamine; USA: Antivert, Meclizine.
Latin America
Brazil: Meclin; Mexico: Chiclida, Liatriz, Marenín.
Drug combinations
Meclizine and Pyridoxine (Vitamin B~6~)
Chemistry
Meclizine Hydrochloride: C~25~H~27~ClN~2~ 2HCl H~2~O. Mw: 481.89. (1) Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride, monohydrate; (2) 1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride monohydrate. CAS-31884-77-2; CAS-1104-22-9 (anhydrous); CAS-569-65-3 (meclizine).
Pharmacologic Category
Antiemetics; Antihistamines; First Generation Histamine H~1~ Antagonist. (ATC-Code: R06AE05).
Mechanism of action
Has central anticholinergic action by blocking chemoreceptor trigger zone. Decreases excitability of middle ear labyrinth and blocks conduction in middle ear vestibular-cerebellar pathways.
Therapeutic use
Prevention and treatment of symptoms of motion sickness. Management of vertigo with diseases affecting vestibular system.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Hypersensitivity to meclizine or any component of the formulation.
Warnings and precautions
Might cause CNS depression. Use with caution in asthma. Use with caution in narrow-angle glaucoma (might be exacerbated by cholinergic blockade). Use with caution in prostatic hyperplasia and/or urinary stricture. Use with caution in pyloric or duodenal obstruction. Use with caution in the elderly. Effects might be potentiated when used with other sedative drugs or ethanol. In case of lack of response it is advised to discontinue use. Some formulations contain tartrazine dye (may cause allergic reactions).