Metaxalone
- Atc Codes:M03BB
- CAS Codes:1665-48-1
- PHARMGKB ID:1665-48-1
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Skelaxin.
Drug combinations
Chemistry
Metaxalone: C~12~H~15~NO~3~. Mw: 221.25. (1) 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-; (2) 5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone. CAS-1665-48-1 (1962).
Pharmacologic Category
Centrally Acting Skeletal Muscle Relaxants. (ATC-Code: M03BB).
Mechanism of action
Efficacy appears to result from disruption of spasm-pain-spasm cycle, probably by general CNS-depressant effect. Does not have direct effect on skeletal muscle.
Therapeutic use
Relief of discomfort associated with acute, painful musculoskeletal conditions.
Pregnancy and lactiation implications
Do not use in women who are or may become pregnant unless possible benefits outweigh potential risks. Use not recommended during lactation.
Unlabeled use
Contraindications
Hypersensitivity to metaxalone or any component of the formulation. Impaired hepatic or renal function, history of drug-induced hemolytic anemias or other anemias.
Warnings and precautions
Might cause CNS depression. Use with caution in hepatic or renal impairment. Effects might be potentiated when used with other sedative drugs or ethanol. Use with caution in the elderly (might be more sensitive to CNS effects). Increase in bioavailability and half-life observed in female patients.