Rimexolone
- Atc Codes:H02AB12#S01BA13
- CAS Codes:49697-38-3
- PHARMGKB ID:49697-38-3
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Vexol; Belgium: Vexolon; Denmark: Vexol; Finland: Vexol; France: Vexol; Germany: Vexol; Greece: Vexol; Ireland: Vexol; Italy: Vexol; Netherlands: Vexol; Portugal: Vexol; Spain: Vexol; Sweden: Vexol; UK: Vexol.
North America
Canada: Vexol; USA: Vexol.
Latin America
Brazil: Vexol; Mexico: Vexol.
Drug combinations
Chemistry
Rimexolone: C~24~H~34~O~3~. Mw: 370.52. (1) Androsta-1,4-dien-3-one, 11-hydroxy-16,17-dimethyl-17-(1-oxopropyl)-, (11β,16α,17β)-; (2) 11β-Hydroxy-16α,17α-dimethyl-17-propionylandrosta-1,4-dien-3-one. CAS-49697-38-3 (1990).
Pharmacologic Category
EENT Preparations; Anti-inflammatory Agents; Corticosteroids. Ophthalmic Corticosteroid. (ATC-Code: H02AB12; S01BA13).
Mechanism of action
Decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability.
Therapeutic use
Treatment of inflammation after ocular surgery and treatment of anterior uveitis.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Hypersensitivity to rimexolone or any component of the formulation. Fungal, viral, or untreated pus-forming bacterial ocular infections.
Warnings and precautions
Steroids may mask infection or enhance existing ocular infection. Prolonged use may result in secondary infections due to immunosuppression. Prolonged use may result in glaucoma and injury to optic nerve. Visual defects in acuity and field of vision may occur. Posterior subcapsular cataracts may form after long-term use. Use with caution in presence of glaucoma (steroids increase intraocular pressure). Perforation may occur with topical steroids in diseases which thin cornea or sclera. Steroid use may delay healing after cataract surgery.