Systemic absorption of topical corticosteroids may cause hypothalamic-pituitary-adrenal axis suppression (reversible) particularly in younger children, which may lead to adrenal crisis. Risk increased when used over large surface areas, for prolonged periods, or with occlusive dressings. Allergic contact dermatitis can occur. Prolonged treatment with corticosteroids associated with development of Kaposi’s sarcoma (case reports). Adverse systemic effects including hyperglycemia, glycosuria, fluid and electrolyte changes, and HPA suppression may occur when used on large surface areas, for prolonged periods, or with occlusive dressing. Should not be used for diaper dermatitis. Chronic use of corticosteroids in children may interfere with growth and development.