Valrubicin
- Atc Codes:L01DB09
- CAS Codes:56124-62-0
- PHARMGKB ID:56124-62-0
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
Canada: Valtaxin; USA: Valstar.
Drug combinations
Chemistry
Valrubicin: C~34~H~36~F~3~NO~13~. Mw: 723.64. (1)(2S-cis)-2-[1,2,3,4,6,11-Hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-2-naphthacenyl]-2-oxoethyl pentanoate; (2)(8S,10S)-8-Glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione 8^2^-valerate. CAS-56124-62-0 (1997).
Pharmacologic Category
Antineoplastic Agents; Cytotoxic Antibiotics and Related Substances; Anthracycline. (ATC-Code: L01DB09).
Mechanism of action
Blocks function of DNA topoisomerase II. Inhibits DNA synthesis, causes extensive chromosomal damage, and arrests cell development.
Therapeutic use
Intravesical therapy of bacillus Calmette-Guérin (BCG)-refractory carcinoma in situ of urinary bladder.
Pregnancy and lactiation implications
There are no adequate, well-controlled studies in pregnant women. Unknown whether valrubicin is secreted in human milk.
Unlabeled use
Contraindications
Hypersensitivity to anthracyclines, or any component of the formulation. Concurrent urinary tract infection or small bladder capacity (unable to tolerate a 75-mL instillation).
Warnings and precautions
Hazardous agent. Red-tinged urine may occur in first 24 hours after instillation. Do not administer if mucosal integrity of bladder has been compromised or bladder perforation present. Irritable bladder symptoms may occur during instillation and retention.