Acetaminophen (Paracetamol)

Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Substrate of
  • Inhibits
  • Induces
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names

Europe

Austria: Ben-u-ron, Duaneo, Grippostad Heißgetränk, Mexalen, Momentum, Para, Paracetamol, Parakapton, Paraspeed, Perfalgan, Trimedil; Belgium: Algostase, Croix Blanche, Dafalgan, Dolol-Instant, Dolprone, Lemsip, Panadol, Paracetamol, Pe-Tam, Perdolan, Perfusalgan, Sanicopyrine; Bulgaria: Apap, Calpol, Daleron, Efferalgan, Grippostad Hot Drink, Panadol, Paracetamol, Perfalgan, Rapidol, Tylol; Cyprus: Analgiser, Apotel, Ben-U-Ron, Calpol, Depon, Panadol, Paracen, Pecramol, Remedol, Six Plus Parapaed; Czech Republic: Ben-U-Ron, Benuron, Daleron, Efferalgan, Medipyrin, Mexalen, Panadol, Paralen, Paramax Rapid, Perfalgan; Denmark: Pamol, Panodil, Perfalgan, Pinex; Estonia: Efferalgan, Grippostad Kuum Jook, Pamol, Panadol, Paracetamol, Paramax, Perfalgan; Finland: Pamol, Panadol, Paraceon, Para-Hot, Paracetamol, Paramax, Perfalgan; France: Algodol, Claradol, Dafalgan, Doliprane, Dolko, Dolotec, Efferalgan, Efferalganodis, Expandox, Febrectol, Geluprane, Panadol, Paracetamol, Paralyoc, Perfalgan, Sedarene; Germany: Anaflon, Apiredol, Apo Cetamol, Ben-u-ron, Captin, Cervopyrin, Dolereduct, Dolflash, Doloreduct, Emtacetamol, Enelfa, Erkältungs, Eu-Med P Mono, Febrifant N, Gelonida P, Germapyrin, Grippex, Grippostad Heißgetränk, Hermamed, Leodolor, Mandrogripp, Mono Praecimed, Morapyrin, Neuralgin Solo, Nilnocen, Ostendpyrin, Paedialgon, Paedol, Panadol, Paracet, Paracetamol, Paramed, Parapaed, Perfalgan, Pracetam, Rubiemol, Sinpro, Sonotemp, Stodinal, Supranat, Toximer, Vivimed; Greece: Algocit, Apotel, Biocetamol, Depon, Dolal, Helporal, Lonarid, Neo-Kalmol, Panadol, Par 500, Paracetamol, Perfalgan, Protalgon, Tempra, Tylenol; Hungary: Ben-u-ron, Efferalgan, Grippostad, Mexalen, Miralgin, Panadol, Paracetamol, Paramax, Perfalgan, Rubophen; Ireland: Calpol, Dolflash, Hedex, Lemsip, Medinol, Panadol, Panagram Max, Paracetamol, Paralief, Paralink, Paratabs, Perfalgan; Italy: Acetamol, Adolef, Baby Rinolo Feb-Dol Os, Efferalgan, Minofen, Normaflu, Panadol, Paraceta, Paracetamolo, Perfalgan, Piros, Sanipirina, Tachipirina, Termol; Latvia: Cefekons, Efferalgan, Febridol, Grippostad Hot Drink, Pamol, Panadol, Paracetamol, Paramax, Perfalgan; Lithuania: Apap, Efferalgan, Grippostad, Pamol, Panadol, Paramax, Perfalgan; Luxembourg: Afebryl, Croix Blanche, Curpol, Dafalgan, Dolprone, Dol-Stop, Efferalgan, Enelfa, Lemgrip, Lonarid, Neuridon, Panadol, Paracetamol, Perdolan Mono, Pe-Tam, Supadol, Tempra; Malta: Abdine, Arfen, Calpol, Enelfa, Medinol, Panadol, Paracetamol, Remedol; Netherlands: Democyl, Hedex Bruis, Momentum, Panadol, Paracetamol, Perfalgan, Tylenol; Poland: Acenol, Amipar, Anadin, Apap, Benuron, Calpol, Codipar, Doliprane, Efferalgan, Etoran, Gemipar, Grippostad, Hascopar, Malupar, Novo-Gesic, Panadol, Paracemol, Paracenol, Paracetamol, Paralen Sus, Paramax Rapid, Perfalgan, Tabcin, Tazamol, Tylenol; Portugal: Anti-Gripe Asclepius, Apiredol, Atralidon, Beluron, Ben-u-ron, Cofedron, Dafalgan, Efferalgan, Febridol, Gelocatil, Kelin, Lisopan, Molpireos, Neogrip, Olpira, Panadol, Panasorbe, Pantadolor, Paracetamol, Paracetol, Paramolan, Parsel, Perfalgan, Singrips, Supofen, Takipirina, Tylenol, Xumadol; Romania: Adol, Apap, Calpol, Daleron, Defebryl, Efferalgan, Panadol, Paracetamol, Paralen, Paramidol, Paramol, Perfalgan, Sanador; Slovakia: Medipyrin, Mexalen, Panadol, Paralen, Perfalgan, Trigrip; Slovenia: Calpol, Daleron, Lekadol, Panadol, Paracetamol; Spain: Acecat, Alador, Antidol, Apiretal, Dafalgan, Dolostop, Duorol, Efferalgan, Febrectal, Gelocatil, Melabon Infantil, Nupeldol, Octomol, Panadol, Paracetamol, Parafludeten, Perfalgan, Resolvebohm, Sinmol, Termalgin, Tylenol, Xumadol; Sweden: Alvedon, Curadon, Pamol, Panodil, Paraceon, Paracut, Perfalgan, Reliv; UK: Anadin, Alvedon, Calpol, Hedex, Medinol, Paldesic, Panadol, Paracetamol, Perfalgan.

North America

Canada: Abenol, Acet, Acetaminophen, Apap, Arthritis Pain Extended Relief, Artritol, Atasol, Children Feverhalt, Fortolin, Novo-Gesic, Panadol, Pediaphen, Pediatrix, Rapid Action, Taminol, Tempra, Tylenol, Vicks Custom Care Body Aches; USA: Acephen, Acetaminophen, Infants’ Feverall, Ofirmev, Neopap, Tylenol.

Latin America

Argentina: Acetolit, Alikal Dolor, Apracur Te Antifebril, Bio Grip, Causalon, Dirox, Fiebrolex, Flash, Inmunogrip, Itedal, Mejoral, Nodipir, Paracetamol, Parclen, Plovacal, Tafirol, Termofren, Vick Vitapyrena, Viclor; Brazil: Acetamil, Acetofen, Anador, Anatyl, Cefabrina, Cyfenol, Dorfenol, Dôrico, Dorsanol, Emsgrip, Fervex-Hertz, Paracen, Paracetamol, Paralgen, Piramin, Pyrimel, Sonridor, Termol, Tilekin, Trifen, Tylecetamol, Tylenol, Tylephen, Tylidol, Unigrip, Vick Pyrena; Mexico: Abatem, Acetafen, Acetif, Alpirex, Amolgen, Analphen, Andox, Antidol, Biofer, Coriver, Datril, Dismifen, Doluvital, Dolviran, Facetol, Farpik, Ferridall, Filanc, Frilen, Icetazol, Infalgina, Mejoral, Mejoralito, Minofen, Neodol, Nordinet, Panofen, Paracetamol, Pharmacen, Piralgina, Piralyn, Piremol, Precifen, Prosedal, Quitadol, Sedalito, Sinedol, Soltadol, Son’s Piral, Tafirol, Temperal, Tempire, Tempofin, Tempra, Temprin, Temzzard, Tylenol, Tylex, Ulpafie.

Asia

Japan: Acetaminophen, Alpiny, Anhiba, Anyrume, Aphlogis, Aspain, Atenemen, Atmiphen, Calonal, Calsil, Cocarl, Napa, Neosedenal, Paraceta, Pyretinol, Pyrinazin, Sarutu, Towasaal.

Drug combinations

Acetaminophen and Ascorbic Acid (Vitamin C)

Acetaminophen and Aspirin

Acetaminophen and Caffeine

Acetaminophen and Carisoprodol

Acetaminophen and Chlorpheniramine

Acetaminophen and Chlorzoxazone

Acetaminophen and Codeine

Acetaminophen and Dextromethorphan

Acetaminophen and Dextropropoxyphene

Acetaminophen and Diclofenac

Acetaminophen and Dihydrocodeine

Acetaminophen and Dimenhydrinate

Acetaminophen and Diphenhydramine

Acetaminophen and Dipyrone

Acetaminophen and Guaifenesin

Acetaminophen and Hydrocodone

Acetaminophen and Ibuprofen

Acetaminophen and Ketoprofen

Acetaminophen and Lidocaine

Acetaminophen and Methocarbamol

Acetaminophen and Metoclopramide

Acetaminophen and Morphine

Acetaminophen and Orphenadrine

Acetaminophen and Oxycodone

Acetaminophen and Pentazocine

Acetaminophen and Phenylephrine

Acetaminophen and Promethazine

Acetaminophen and Propoxyphene

Acetaminophen and Propyphenazone

Acetaminophen and Pseudoephedrine

Acetaminophen and Scopolamine

Acetaminophen and Tramadol

Acetaminophen, Amantadine, and Chlorpheniramine

Acetaminophen, Amantadine, and Phenylephrine

Acetaminophen, Ambroxol, and Oxatomide

Acetaminophen, Ascorbic Acid (Vitamin C), and Aspirin

Acetaminophen, Ascorbic Acid (Vitamin C), and Caffeine

Acetaminophen, Ascorbic Acid (Vitamin C), and Chlorpheniramine

Acetaminophen, Ascorbic Acid (Vitamin C), and Phenylephrine

Acetaminophen, Aspirin, and Caffeine

Acetaminophen, Aspirin, and Codeine

Acetaminophen, Bromhexine, and Pseudoephedrine

Acetaminophen, Butalbital, and Caffeine

Acetaminophen, Caffeine, and Carbasalate Calcium

Acetaminophen, Caffeine, and Codeine

Acetaminophen, Caffeine, and Dihydrocodeine

Acetaminophen, Caffeine, and Guaifenesin

Acetaminophen, Caffeine, and Phenylephrine

Acetaminophen, Caffeine, and Propyphenazone

Acetaminophen, Chlorzoxazone and Dexamethasone

Acetaminophen, Chlorpheniramine, and Phenylephrine

Acetaminophen, Chlorpheniramine, and Pseudoephedrine

Acetaminophen, Clemastine, and Pseudoephedrine

Acetaminophen, Dexbrompheniramine, and Pseudoephedrine

Acetaminophen, Dextromethorphan, and Doxylamine

Acetaminophen, Dextromethorphan, and Phenylephrine

Acetaminophen, Dextromethorphan, and Promethazine

Acetaminophen, Dextromethorphan, and Pseudoephedrine

Acetaminophen, Diphenhydramine, and Ascorbic Acid (Vitamin C)

Acetaminophen, Diphenhydramine, and Pseudoephedrine

Acetaminophen, Guaifenesin, and Phenylephrine

Acetaminophen, Loratadine, and Pseudoephedrine

Acetaminophen, Pamabrom, and Pyrilamine

Acetaminophen, Pholcodine, and Pseudoephedrine

Acetaminophen, Propyphenazone, and Caffeine

Acetaminophen, Pseudoephedrine, and Triprolidine

Acetaminophen, Pyridoxine (Vitamin B~6~), and Thiamine

Acetaminophen, Ascorbic Acid (Vitamin C), Brompheniramine, and Caffeine

Acetaminophen, Ascorbic Acid (Vitamin C), Caffeine, and Chlorpheniramine

Acetaminophen, Ascorbic Acid (Vitamin C), Dexbrompheniramine, and Pseudoephedrine

Acetaminophen, Ascorbic Acid (Vitamin C), Diphenylpyraline, and Ethenzamide

Acetaminophen, Ascorbic Acid (Vitamin C), Guaifenesin, and Phenylephrine

Acetaminophen, Ascorbic Acid (Vitamin C), Pheniramine, and Phenylephrine

Acetaminophen, Ascorbic Acid (Vitamin C), Phenylephrine, and Salicylamide

Acetaminophen, Bromhexine, Chlorpheniramine, and Pseudoephedrine

Acetaminophen, Bromhexine, Loratadine, and Pseudoephedrine

Acetaminophen, Butalbital, Caffeine, and Codeine

Acetaminophen, Butetamate, Caffeine, and Phenylephrine

Acetaminophen, Butetamate, Chlorpheniramine, and Pseudoephedrine

Acetaminophen, Caffeine, Chlorpheniramine, and Ergotamine

Acetaminophen, Caffeine, Codeine, and Scopolamine

Acetaminophen, Caffeine, Morphine, and Opium

Acetaminophen, Chlorpheniramine, Dextromethorphan, and Pseudoephedrine

Acetaminophen, Cyanocobalamin (Vitamin B~12~), Pyridoxine (Vitamin B~6~), and Thiamine (Vitamin B~1~)

Acetaminophen, Dextromethorphan, Doxylamine, and Ephedrine

Acetaminophen, Dextromethorphan, Doxylamine, and Pseudoephedrine

Acetaminophen, Dextromethorphan, Guaifenesin, and Pseudoephedrine

Acetaminophen, Guaifenesin, Oxomemazine, and Sodium Benzoate

Acetaminophen, Aluminum Hydroxide, Aspirin, Caffeine, and Magnesium Hydroxide

Acetaminophen, Ascorbic Acid (Vitamin C), Aspartame, Citric Acid, and Phenylephrine

Acetaminophen, Bromhexine, Chlorpheniramine, Dextromethorphan, and Phenylephrine

Acetaminophen, Caffeine, Codeine, Dipyrone, and Phenobarbital

Acetaminophen, Caffeine, Propyphenazone, Pyridoxine (Vitamin B~6~), and Sodium Benzoate

Acetaminophen, Ascorbic Acid (Vitamin C), Caffeine, Codeine, Diphenhydramine, and Phenylephrine

Chemistry

Acetaminophen: C~8~H~9~NO~2~. Mw: 151.16. (1) Acetamide, N-(4-hydroxyphenyl)-; (2) 4′-Hydroxyacetanilide. CAS-103-90-2.

Pharmacologic Category

Analgesics and Antipyretics, Miscellaneous. (ATC-Code: N02BE01).

Mechanism of action

Inhibits prostaglandin synthesis in the central nervous system and peripherally blocks pain impulse generation. Produces antipyresis from inhibition of hypothalamic heat-regulating center.

Therapeutic use

Treatment of pain and fever (antipyretic/analgesic). Does not have antirheumatic or anti-inflammatory effects.

Pregnancy and lactiation implications

Safe for use during pregnancy when used at therapeutic doses for short periods of time. Compatible with lactation.

Unlabeled use

Contraindications

Hypersensitivity to acetaminophen or any component of the formulation.

Warnings and precautions

May cause hepatic toxicity (on acute overdose). Use with caution in alcoholic liver disease and in G6PD deficiency. Dose should be limited to <4 g/day.

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