Acamprosate
- Atc Codes:N07BB03
- CAS Codes:77337-73-6#77337-76-9
- PHARMGKB ID:77337-73-6#77337-76-9
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Campral; Belgium: Campral; Czech Republic: Campral; Denmark: Campral; France: Aotal; Germany: Campral; Hungary: Campral; Ireland: Campral; Netherlands: Campral; Poland: Campral; Portugal: Campral; Spain: Campral, Zulex; Sweden: Aotal, Campral; UK: Campral.
North America
Canada: Campral; USA: Campral.
Latin America
Mexico: Campral.
Drug combinations
Chemistry
Acamprosate Calcium: C~10~H~20~CaN~2~O~8~S~2~. Mw: 400.48. (1) 1-Propanesulfonic acid, 3-(acetylamino)-, calcium salt (2:1); (2) Calcium 3-(acetylamino)propane-1-sulfonate. CAS-77337-73-6; CAS-77337-76-9 (acamprosate)(2002).
Pharmacologic Category
Central Nervous System Agents, Miscellaneous; GABA Agonist/Glutamate Antagonists. (ATC-Code: N07BB03).
Mechanism of action
Increases GABA-ergic system activity and decreases glutamate activity, including a decrease in activity at N-methyl D-aspartate (NMDA) receptors. Restores balance to disrupted GABA and glutamate activities in alcohol dependence. Reduces alcohol intake.
Therapeutic use
Maintenance of alcohol abstinence.
Pregnancy and lactiation implications
Use only if potential benefit outweighs possible risk to the fetus. Caution during lactation.
Unlabeled use
Contraindications
Hypersensitivity to acamprosate or any component of the formulation. Severe renal impairment (CrCl <30 mL/minute).
Warnings and precautions
Caution in depression and suicidal ideation. Does not eliminate/diminish symptoms of alcohol withdrawal. Caution in moderate renal impairment (CrCl 30-50 mL/minute). Contraindicated in severe renal impairment. May contain sulfites.