Acebutolol
- Atc Codes:C07AB04
- CAS Codes:37517-30-9#34381-68-5
- PHARMGKB ID:37517-30-9#34381-68-5
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Belgium: Acebutolol, Sectral; Czech Republic: Acebutolol, Acecor, Apo-Acebutol, Sectral; Denmark: Diasectral; Finland: Diasectral, Espesil; France: Acebutolol, Sectral; Germany: Acebutolol, Prent, Tredalat; Italy: Prent, Sectral; Luxembourg: Acebutolol, Sectral; Netherlands: Acebutolol, Sectral; Poland: Abutol, Acebutolol, Acecor, Sectral; Portugal: Prent; Slovakia: Acecor; UK: Acebutolol, Sectral.
North America
Canada: Acebutolol, Rhotral, Sectral; USA: Acebutolol, Sectral.
Asia
Japan: Acebutolol, Acetanol, Sectral.
Drug combinations
Acebutolol and Hydrochlorothiazide
Acebutolol and Nifedipine
Chemistry
Acebutolol: C~18~H~28~N~2~O~4~. Mw: 336.43. (1) Butanamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-, (±)-; (2)(±)-3′-Acetyl-4′-[2-hydroxy-3-(isopropylamino)propoxy]butyranilide. CAS-37517-30-9 (1973).
Acebutolol Hydrochloride: C~18~H~28~N~2~O~4~ HCl. Mw: 372.89. (±)-3′-Acetyl-4′-[2-hydroxy-3-(isopropylamino)propoxy]butyranilide monohydrochloride. CAS-34381-68-5.
Pharmacologic Category
Class II Antiarrhythmic Agents; β-Adrenergic Blocking Agents (Intrinsic Sympathomimetic Activity). (ATC-Code: C07AB04).
Mechanism of action
Competitively blocks β~1~-adrenergic receptors with little or no effect on β~2~-receptors, except at high doses. Membrane-stabilizing and intrinsic sympathomimetic activity.
Therapeutic use
Treatment of hypertension. Management of ventricular arrhythmias.
Pregnancy and lactiation implications
Acebutolol and its metabolite cross the human placenta. β-Blockers are generally safe during pregnancy. Use not recommended during lactation.
Unlabeled use
Treatment of chronic stable angina.
Contraindications
Overt cardiac failure. Cardiogenic shock. Persistently-severe bradycardia or second- and third-degree heart block (except in patients with a functioning artificial pacemaker).
Warnings and precautions
Anaphylactic reactions (use caution in history of severe anaphylaxis to allergens). Avoid use in bronchospastic disease and in heart failure. Caution in the following cases: diabetes mellitus (may potentiate hypoglycemia and/or mask signs and symptoms), hepatic and renal impairment, mesenteric or peripheral vascular disease (may precipitate or aggravate symptoms of arterial insufficiency), myasthenia gravis, psychiatric illness (may cause or exacerbate CNS depression), Raynaud’s disease (may precipitate symptoms), pheochromocytoma, or thyrotoxicosis (may mask signs of hyperthyroidism). Should not be withdrawn abruptly (may cause acute tachycardia and hypertension).