Acetaminophen (Paracetamol)
- Atc Codes:N02BE01
- CAS Codes:103-90-2
- PHARMGKB ID:103-90-2
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Induces
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Ben-u-ron, Duaneo, Grippostad Heißgetränk, Mexalen, Momentum, Para, Paracetamol, Parakapton, Paraspeed, Perfalgan, Trimedil; Belgium: Algostase, Croix Blanche, Dafalgan, Dolol-Instant, Dolprone, Lemsip, Panadol, Paracetamol, Pe-Tam, Perdolan, Perfusalgan, Sanicopyrine; Bulgaria: Apap, Calpol, Daleron, Efferalgan, Grippostad Hot Drink, Panadol, Paracetamol, Perfalgan, Rapidol, Tylol; Cyprus: Analgiser, Apotel, Ben-U-Ron, Calpol, Depon, Panadol, Paracen, Pecramol, Remedol, Six Plus Parapaed; Czech Republic: Ben-U-Ron, Benuron, Daleron, Efferalgan, Medipyrin, Mexalen, Panadol, Paralen, Paramax Rapid, Perfalgan; Denmark: Pamol, Panodil, Perfalgan, Pinex; Estonia: Efferalgan, Grippostad Kuum Jook, Pamol, Panadol, Paracetamol, Paramax, Perfalgan; Finland: Pamol, Panadol, Paraceon, Para-Hot, Paracetamol, Paramax, Perfalgan; France: Algodol, Claradol, Dafalgan, Doliprane, Dolko, Dolotec, Efferalgan, Efferalganodis, Expandox, Febrectol, Geluprane, Panadol, Paracetamol, Paralyoc, Perfalgan, Sedarene; Germany: Anaflon, Apiredol, Apo Cetamol, Ben-u-ron, Captin, Cervopyrin, Dolereduct, Dolflash, Doloreduct, Emtacetamol, Enelfa, Erkältungs, Eu-Med P Mono, Febrifant N, Gelonida P, Germapyrin, Grippex, Grippostad Heißgetränk, Hermamed, Leodolor, Mandrogripp, Mono Praecimed, Morapyrin, Neuralgin Solo, Nilnocen, Ostendpyrin, Paedialgon, Paedol, Panadol, Paracet, Paracetamol, Paramed, Parapaed, Perfalgan, Pracetam, Rubiemol, Sinpro, Sonotemp, Stodinal, Supranat, Toximer, Vivimed; Greece: Algocit, Apotel, Biocetamol, Depon, Dolal, Helporal, Lonarid, Neo-Kalmol, Panadol, Par 500, Paracetamol, Perfalgan, Protalgon, Tempra, Tylenol; Hungary: Ben-u-ron, Efferalgan, Grippostad, Mexalen, Miralgin, Panadol, Paracetamol, Paramax, Perfalgan, Rubophen; Ireland: Calpol, Dolflash, Hedex, Lemsip, Medinol, Panadol, Panagram Max, Paracetamol, Paralief, Paralink, Paratabs, Perfalgan; Italy: Acetamol, Adolef, Baby Rinolo Feb-Dol Os, Efferalgan, Minofen, Normaflu, Panadol, Paraceta, Paracetamolo, Perfalgan, Piros, Sanipirina, Tachipirina, Termol; Latvia: Cefekons, Efferalgan, Febridol, Grippostad Hot Drink, Pamol, Panadol, Paracetamol, Paramax, Perfalgan; Lithuania: Apap, Efferalgan, Grippostad, Pamol, Panadol, Paramax, Perfalgan; Luxembourg: Afebryl, Croix Blanche, Curpol, Dafalgan, Dolprone, Dol-Stop, Efferalgan, Enelfa, Lemgrip, Lonarid, Neuridon, Panadol, Paracetamol, Perdolan Mono, Pe-Tam, Supadol, Tempra; Malta: Abdine, Arfen, Calpol, Enelfa, Medinol, Panadol, Paracetamol, Remedol; Netherlands: Democyl, Hedex Bruis, Momentum, Panadol, Paracetamol, Perfalgan, Tylenol; Poland: Acenol, Amipar, Anadin, Apap, Benuron, Calpol, Codipar, Doliprane, Efferalgan, Etoran, Gemipar, Grippostad, Hascopar, Malupar, Novo-Gesic, Panadol, Paracemol, Paracenol, Paracetamol, Paralen Sus, Paramax Rapid, Perfalgan, Tabcin, Tazamol, Tylenol; Portugal: Anti-Gripe Asclepius, Apiredol, Atralidon, Beluron, Ben-u-ron, Cofedron, Dafalgan, Efferalgan, Febridol, Gelocatil, Kelin, Lisopan, Molpireos, Neogrip, Olpira, Panadol, Panasorbe, Pantadolor, Paracetamol, Paracetol, Paramolan, Parsel, Perfalgan, Singrips, Supofen, Takipirina, Tylenol, Xumadol; Romania: Adol, Apap, Calpol, Daleron, Defebryl, Efferalgan, Panadol, Paracetamol, Paralen, Paramidol, Paramol, Perfalgan, Sanador; Slovakia: Medipyrin, Mexalen, Panadol, Paralen, Perfalgan, Trigrip; Slovenia: Calpol, Daleron, Lekadol, Panadol, Paracetamol; Spain: Acecat, Alador, Antidol, Apiretal, Dafalgan, Dolostop, Duorol, Efferalgan, Febrectal, Gelocatil, Melabon Infantil, Nupeldol, Octomol, Panadol, Paracetamol, Parafludeten, Perfalgan, Resolvebohm, Sinmol, Termalgin, Tylenol, Xumadol; Sweden: Alvedon, Curadon, Pamol, Panodil, Paraceon, Paracut, Perfalgan, Reliv; UK: Anadin, Alvedon, Calpol, Hedex, Medinol, Paldesic, Panadol, Paracetamol, Perfalgan.
North America
Canada: Abenol, Acet, Acetaminophen, Apap, Arthritis Pain Extended Relief, Artritol, Atasol, Children Feverhalt, Fortolin, Novo-Gesic, Panadol, Pediaphen, Pediatrix, Rapid Action, Taminol, Tempra, Tylenol, Vicks Custom Care Body Aches; USA: Acephen, Acetaminophen, Infants’ Feverall, Ofirmev, Neopap, Tylenol.
Latin America
Argentina: Acetolit, Alikal Dolor, Apracur Te Antifebril, Bio Grip, Causalon, Dirox, Fiebrolex, Flash, Inmunogrip, Itedal, Mejoral, Nodipir, Paracetamol, Parclen, Plovacal, Tafirol, Termofren, Vick Vitapyrena, Viclor; Brazil: Acetamil, Acetofen, Anador, Anatyl, Cefabrina, Cyfenol, Dorfenol, Dôrico, Dorsanol, Emsgrip, Fervex-Hertz, Paracen, Paracetamol, Paralgen, Piramin, Pyrimel, Sonridor, Termol, Tilekin, Trifen, Tylecetamol, Tylenol, Tylephen, Tylidol, Unigrip, Vick Pyrena; Mexico: Abatem, Acetafen, Acetif, Alpirex, Amolgen, Analphen, Andox, Antidol, Biofer, Coriver, Datril, Dismifen, Doluvital, Dolviran, Facetol, Farpik, Ferridall, Filanc, Frilen, Icetazol, Infalgina, Mejoral, Mejoralito, Minofen, Neodol, Nordinet, Panofen, Paracetamol, Pharmacen, Piralgina, Piralyn, Piremol, Precifen, Prosedal, Quitadol, Sedalito, Sinedol, Soltadol, Son’s Piral, Tafirol, Temperal, Tempire, Tempofin, Tempra, Temprin, Temzzard, Tylenol, Tylex, Ulpafie.
Asia
Japan: Acetaminophen, Alpiny, Anhiba, Anyrume, Aphlogis, Aspain, Atenemen, Atmiphen, Calonal, Calsil, Cocarl, Napa, Neosedenal, Paraceta, Pyretinol, Pyrinazin, Sarutu, Towasaal.
Drug combinations
Acetaminophen and Ascorbic Acid (Vitamin C)
Acetaminophen and Aspirin
Acetaminophen and Caffeine
Acetaminophen and Carisoprodol
Acetaminophen and Chlorpheniramine
Acetaminophen and Chlorzoxazone
Acetaminophen and Codeine
Acetaminophen and Dextromethorphan
Acetaminophen and Dextropropoxyphene
Acetaminophen and Diclofenac
Acetaminophen and Dihydrocodeine
Acetaminophen and Dimenhydrinate
Acetaminophen and Diphenhydramine
Acetaminophen and Dipyrone
Acetaminophen and Guaifenesin
Acetaminophen and Hydrocodone
Acetaminophen and Ibuprofen
Acetaminophen and Ketoprofen
Acetaminophen and Lidocaine
Acetaminophen and Methocarbamol
Acetaminophen and Metoclopramide
Acetaminophen and Morphine
Acetaminophen and Orphenadrine
Acetaminophen and Oxycodone
Acetaminophen and Pentazocine
Acetaminophen and Phenylephrine
Acetaminophen and Promethazine
Acetaminophen and Propoxyphene
Acetaminophen and Propyphenazone
Acetaminophen and Pseudoephedrine
Acetaminophen and Scopolamine
Acetaminophen and Tramadol
Acetaminophen, Amantadine, and Chlorpheniramine
Acetaminophen, Amantadine, and Phenylephrine
Acetaminophen, Ambroxol, and Oxatomide
Acetaminophen, Ascorbic Acid (Vitamin C), and Aspirin
Acetaminophen, Ascorbic Acid (Vitamin C), and Caffeine
Acetaminophen, Ascorbic Acid (Vitamin C), and Chlorpheniramine
Acetaminophen, Ascorbic Acid (Vitamin C), and Phenylephrine
Acetaminophen, Aspirin, and Caffeine
Acetaminophen, Aspirin, and Codeine
Acetaminophen, Bromhexine, and Pseudoephedrine
Acetaminophen, Butalbital, and Caffeine
Acetaminophen, Caffeine, and Carbasalate Calcium
Acetaminophen, Caffeine, and Codeine
Acetaminophen, Caffeine, and Dihydrocodeine
Acetaminophen, Caffeine, and Guaifenesin
Acetaminophen, Caffeine, and Phenylephrine
Acetaminophen, Caffeine, and Propyphenazone
Acetaminophen, Chlorzoxazone and Dexamethasone
Acetaminophen, Chlorpheniramine, and Phenylephrine
Acetaminophen, Chlorpheniramine, and Pseudoephedrine
Acetaminophen, Clemastine, and Pseudoephedrine
Acetaminophen, Dexbrompheniramine, and Pseudoephedrine
Acetaminophen, Dextromethorphan, and Doxylamine
Acetaminophen, Dextromethorphan, and Phenylephrine
Acetaminophen, Dextromethorphan, and Promethazine
Acetaminophen, Dextromethorphan, and Pseudoephedrine
Acetaminophen, Diphenhydramine, and Ascorbic Acid (Vitamin C)
Acetaminophen, Diphenhydramine, and Pseudoephedrine
Acetaminophen, Guaifenesin, and Phenylephrine
Acetaminophen, Loratadine, and Pseudoephedrine
Acetaminophen, Pamabrom, and Pyrilamine
Acetaminophen, Pholcodine, and Pseudoephedrine
Acetaminophen, Propyphenazone, and Caffeine
Acetaminophen, Pseudoephedrine, and Triprolidine
Acetaminophen, Pyridoxine (Vitamin B~6~), and Thiamine
Acetaminophen, Ascorbic Acid (Vitamin C), Brompheniramine, and Caffeine
Acetaminophen, Ascorbic Acid (Vitamin C), Caffeine, and Chlorpheniramine
Acetaminophen, Ascorbic Acid (Vitamin C), Dexbrompheniramine, and Pseudoephedrine
Acetaminophen, Ascorbic Acid (Vitamin C), Diphenylpyraline, and Ethenzamide
Acetaminophen, Ascorbic Acid (Vitamin C), Guaifenesin, and Phenylephrine
Acetaminophen, Ascorbic Acid (Vitamin C), Pheniramine, and Phenylephrine
Acetaminophen, Ascorbic Acid (Vitamin C), Phenylephrine, and Salicylamide
Acetaminophen, Bromhexine, Chlorpheniramine, and Pseudoephedrine
Acetaminophen, Bromhexine, Loratadine, and Pseudoephedrine
Acetaminophen, Butalbital, Caffeine, and Codeine
Acetaminophen, Butetamate, Caffeine, and Phenylephrine
Acetaminophen, Butetamate, Chlorpheniramine, and Pseudoephedrine
Acetaminophen, Caffeine, Chlorpheniramine, and Ergotamine
Acetaminophen, Caffeine, Codeine, and Scopolamine
Acetaminophen, Caffeine, Morphine, and Opium
Acetaminophen, Chlorpheniramine, Dextromethorphan, and Pseudoephedrine
Acetaminophen, Cyanocobalamin (Vitamin B~12~), Pyridoxine (Vitamin B~6~), and Thiamine (Vitamin B~1~)
Acetaminophen, Dextromethorphan, Doxylamine, and Ephedrine
Acetaminophen, Dextromethorphan, Doxylamine, and Pseudoephedrine
Acetaminophen, Dextromethorphan, Guaifenesin, and Pseudoephedrine
Acetaminophen, Guaifenesin, Oxomemazine, and Sodium Benzoate
Acetaminophen, Aluminum Hydroxide, Aspirin, Caffeine, and Magnesium Hydroxide
Acetaminophen, Ascorbic Acid (Vitamin C), Aspartame, Citric Acid, and Phenylephrine
Acetaminophen, Bromhexine, Chlorpheniramine, Dextromethorphan, and Phenylephrine
Acetaminophen, Caffeine, Codeine, Dipyrone, and Phenobarbital
Acetaminophen, Caffeine, Propyphenazone, Pyridoxine (Vitamin B~6~), and Sodium Benzoate
Acetaminophen, Ascorbic Acid (Vitamin C), Caffeine, Codeine, Diphenhydramine, and Phenylephrine
Chemistry
Acetaminophen: C~8~H~9~NO~2~. Mw: 151.16. (1) Acetamide, N-(4-hydroxyphenyl)-; (2) 4′-Hydroxyacetanilide. CAS-103-90-2.
Pharmacologic Category
Analgesics and Antipyretics, Miscellaneous. (ATC-Code: N02BE01).
Mechanism of action
Inhibits prostaglandin synthesis in the central nervous system and peripherally blocks pain impulse generation. Produces antipyresis from inhibition of hypothalamic heat-regulating center.
Therapeutic use
Treatment of pain and fever (antipyretic/analgesic). Does not have antirheumatic or anti-inflammatory effects.
Pregnancy and lactiation implications
Safe for use during pregnancy when used at therapeutic doses for short periods of time. Compatible with lactation.
Unlabeled use
Contraindications
Hypersensitivity to acetaminophen or any component of the formulation.
Warnings and precautions
May cause hepatic toxicity (on acute overdose). Use with caution in alcoholic liver disease and in G6PD deficiency. Dose should be limited to <4 g/day.