Acetohydroxamic Acid
- Atc Codes:G04BX03
- CAS Codes:546-88-3
- PHARMGKB ID:546-88-3
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Special Considerations
Brand Names
Europe
Luxembourg: Uronefrex; Spain: Uronefrex.
North America
USA: Lithostat.
Drug combinations
Chemistry
Acetohydroxamic Acid: C~2~H~5~NO~2~. Mw: 75.07. N-Acetyl hydroxyacetamide. CAS-546-88-3 (1984).
Pharmacologic Category
Urologicals; Ammonia Detoxicants. (ATC-Code: G04BX03).
Mechanism of action
Inhibits bacterial urease enzymes, decreasing the formation of ammonia in the urine by urea-splitting organisms.
Therapeutic use
Adjunctive therapy in chronic urea-splitting urinary infection.
Pregnancy and lactiation implications
Not recommended during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to acetohydroxamic acid or any component of the formulation. Pregnancy.
Warnings and precautions
May cause bone marrow suppression. Associated with hemolytic anemia (Coombs’ negative), which may be associated with gastrointestinal distress and systemic symptoms. May cause hepatic injury. Use with caution in pre-existing psychiatric disorders (may be associated with nervousness, anxiety, and/or depression). Not recommended for use in significant renal impairment (Sr~cr~>2.5 mg/dL).