Acetylcysteine
- Atc Codes:R05CB01#S01XA08#V03AB23
- CAS Codes:616-91-1
- PHARMGKB ID:616-91-1
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: ACC, Aeromuc, Aerosolv, Fluimucil, Husten, Hustenlöser, Mucobene; Belgium: Acetylcysteine, Docacetyl, Lysomucil, Lysox, Pectomucil; Bulgaria: ACC, Fluimucil; Cyprus: ACC, Acetylcysteine, Mucomyst, Solmucol; Czech Republic: ACC, Fluimucil, Solmucol; Denmark: Granon, Kuril, Mucolysin, Mucomyst; Estonia: ACC, Acetylcysteine, Bronchostad, Muco-Mepha, Mucofluid; Finland: Mucomyst, Mucoporetta; France: Acetylcysteine, Euronac, Exomuc, Fluimucil, Genac, Humex Expectorant, Mucolator, Mucomyst, Mucomystendo, Mucospire, Solmucol; Germany: ACC, Acemuc, Acetabs, Acetylcysteine, Acetyst, Bomucil, Bromuc, Bronchowieb, Equimuc, Equimucin, Fluibon, Fluimucil, Fluinac, Myxofat, NAC; Greece: ACC, Chricetyl, Fluimucil, Kantrenol, Mucomyst, Solmucol, Trebon-N, Vaden, Vlenolys; Hungary: ACC, Fluimucil, Mucolin, Rinofluimucil, Solmucol, Sputopur; Italy: Acetilcisteina, Altersol, Brunac, Fluimucil, Hidonac, Mucisol, Mucofial, Mucofrin, Mucomucil, Mucoxan, Solmucol, Tirocular; Latvia: ACC, Acetylcystein, Muco, Mucofluid; Lithuania: ACC, Acetylcysteine, Muco-Mepha, Mucofluid; Luxembourg: ACC, Acetylcysteine, Exomuc, Fluimiquil, Lisos, Lysomucil, Mucolair, Mucolator, Mucolyticum, Mucomyst, NAC, Pectomucil, Rumicil, Solmucol, Touxium; Malta: Acetylcysteine, Parvolex; Netherlands: Acetylcysteine, Bisolbruis, Fluimucil; Poland: ACC, Acetylcysteine, Acypront, Fluimucil, Syntemucol, Tussicom; Portugal: Acetilcisteína, Cêtussin, Fluimucil, Flumil, Mucolator, Pulmosal, Rinofluimucil; Romania: ACC, Acetilcisteina, Brunac, Fluimucil, Hidonac, Mucovim; Slovakia: ACC, Solmucol; Slovenia: Fluimukan; Spain: Acetilcisteína, Fluimucil, Flumil; Sweden: Acetylcysteine, Mucomyst, Viskoferm; UK: Parvolex.
North America
Canada: Acetylcysteine, Mucomyst, Parvolex; USA: Acetadote, Acetylcysteine.
Latin America
Argentina: ACC, Acemuk; Brazil: Acetilcisteína, Bromuc, Flucistein, Fluimucil, Fluiteína, Mucocetil, NAC; Mexico: ACC.
Asia
Japan: Acetein, Acetylcysteine, Mucofilin, Sateritt.
Drug combinations
Acetylcysteine: Alanine; Arginine; Aspartic Acid; Calcium Chloride; Glutamic Acid; Glycine; Histidine; Isoleucine; L-Asparagine; Leucine; L-Methionine; L-Ornithine; L-Serine; L-Lysine; Phenylalanine; Proline; Sodium Acetate; Sodium Phosphate; Threonine; Tryptophan; Tyrosine; Valine
Chemistry
Acetylcysteine: C~5~H~9~NO~3~S. Mw: 163.19. N-Acetyl-L-cysteine. CAS-616-91-1 (1963).
Pharmacologic Category
Antidotes. Mucolytic Agents. (ATC-Code: R05CB01; S01XA08; V03AB23).
Mechanism of action
Mucolytic action by opening up the disulfide bonds in the mucoproteins through its free sulfhydryl group.
Therapeutic use
Adjunctive mucolytic therapy in acute and chronic bronchopulmonary disease. Pulmonary complications of surgery and cystic fibrosis. Diagnostic bronchial studies. Antidote for acute acetaminophen toxicity.
Pregnancy and lactiation implications
May provide protective levels in the fetus. Caution during lactation.
Unlabeled use
Prevention of radiocontrast-induced renal dysfunction. Distal intestinal obstruction syndrome.
Contraindications
Hypersensitivity to acetylcysteine or any component of the formulation.
Warnings and precautions
When used as antidote for acetaminophen overdosage, oral administration of acetylcysteine may result in vomiting. Upper GI hemorrhage and acetaminophen-induced hepatotoxicity. Generalized urticaria or other allergic symptoms. Anaphylactoid reaction. Caution in asthma or bronchospasm.