Agalsidase Beta

Table of contents

  • Brand Names
  • Chemistry
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics

Brand Names


Austria: Fabrazyme; Belgium: Fabrazyme; Bulgaria: Fabrazyme; Cyprus: Fabrazyme; Czech Republic: Fabrazyme; Denmark: Fabrazyme; Estonia: Fabrazyme; Finland: Fabrazyme; France: Fabrazyme; Germany: Fabrazyme; Greece: Fabrazyme; Hungary: Fabrazyme; Ireland: Fabrazyme; Italy: Fabrazyme; Latvia: Fabrazyme; Lithuania: Fabrazyme; Luxembourg: Fabrazyme; Malta: Fabrazyme; Netherlands: Fabrazyme; Poland: Fabrazyme; Portugal: Fabrazyme; Romania: Fabrazyme; Slovakia: Fabrazyme; Slovenia: Fabrazyme; Spain: Fabrazyme; Sweden: Fabrazyme; UK: Fabrazyme.

North America

Canada: Fabrazyme; USA: Fabrazyme.


Japan: Fabrazyme.

Drug combinations


Agalsidase Beta: C~2029~H~3080~N~544~O~587~S~27~ (subunit protein moiety reduced). α-Galactosidase (human clone λAG^18^ isoenzyme A subunit protein moiety reduced), glycoform β. CAS-104138-64-9.

Pharmacologic Category

Enzymes. (ATC-Code: A16AB04).

Pharmacologic Category

Mechanism of action

Catalyzes the hydrolysis of globotriaosylceramide (Gb-3) and other glycosphingolipids.

Therapeutic use

Replacement therapy for Fabry disease.

Pregnancy and lactiation implications

Animal reproduction studies have not demonstrated adverse effects. There are as yet no adequate studies in pregnant women. Use with caution during pregnancy or lactation.

Unlabeled use


Hypersensitivity to agalsidase beta or any component of the formulation.

Warnings and precautions

Patients might develop IgG and IgE antibody formation. Infusion-related reactions are common (may be severe). Use with caution in cardiovascular disease (increased risk of complications from infusion reactions).



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