Albuterol (Salbutamol)
- Atc Codes:R03AC02
- CAS Codes:18559-94-9#51022-70-9
- PHARMGKB ID:18559-94-9#51022-70-9
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Butovent; Belgium: Airomir, Docsalbuta, Ecosal, Novolizer Salbutamol, Ventolin; Bulgaria: Buto-Asma, Ecosal, Salbutamol, Ventolin; Cyprus: Medolin, Salamol, Ventolin; Czech Republic: Buventol, Ecosal, Salbutamol, Ventilastin, Ventolin; Denmark: Airomir, Buventol, Salamol, Salbutamol, Salbuvent, Ventoline; Estonia: Buventol, Ecosal, Salbutamol, Ventilastin, Ventolin; Finland: Airomir, Buventol, Ventilastin, Ventoline; France: Airomir, Asmasal, Salbumol, Salbutamol, Ventilastin, Ventoline; Germany: Apsomol, Broncho Inhalat, Epaq, Loftan, Pädiamol, Pentamol, Salbubronch, Salbulair, Salbulind, Salbupp, Salbutamol, Sultanol, Ventilastin, Volmac, Volmax; Greece: Aerolin, Asthmotrat, Normobron, Salbunova, Salbutamol; Hungary: Buventol, Ecosal, Salbutamol, Ventolin; Ireland: Aerolin, Asmasal, Gerivent, Salamol, Salbutamol, Ventamol, Ventolin; Italy: Broncovaleas, Ventmax, Ventolin; Latvia: Buventol, Salbutamol, Ventilastin, Ventolin; Lithuania: Salbutamol, Ventolin; Luxembourg: Airomir, Salbulin, Ventodisk, Ventolin; Malta: Salamol, Ventolin, Volmax; Netherlands: Airomir, Salbutamol, Ventolin; Poland: Buventol, Salamol, Salbupart, Salbutamol, Salbuvent, Velaspir, Ventodisk, Ventolin; Portugal: Airomir, Salbulair, Salbutamol, Ventilan; Romania: Asthalin, Ecosal, Salbutamol, Ventolin; Slovakia: Ecosal, Salbutamol, Ventolin; Slovenia: Ventolin; Spain: Aldobronquial, Buto-Air, Buto-Asma, Respiroma, Salbutamol, Ventilastin, Ventolin; Sweden: Airomir, Buventol, Sabufarm, Sabumalin, Salbutamol, Sanohex, Ventilastin, Ventoline; UK: Salbulin, Salbutamol, Ventolin.
North America
Canada: Airomir, Apo-Salvent, Salbutamol, Ventolin; USA: AccuNeb, ProAir, Proventil, Ventolin, VoSpire.
Latin America
Argentina: Airsalbu, Amocasín, Asmatol, Butamol, Cercini, Duopack, Microterol, Nebutrax, Respiret, Salbutamol, Salbutol, Salbutral, Venticil, Ventimol, Ventolín, Yontal, Zoom; Brazil: Aerodini, Aerogold, Aerogreen, Aerojet, Aerolin, Asmakil, Asmaliv, Bronconal, Butovent, Dilamol-Salbutamol, Prodotamol, Pulmoflux, Salbutam, Salbutamax, Salbutamol, Tussiliv; Mexico: Apo-Salvent, Assal, Avedox, Biorenyn, Capacit, Cobamol, Exafil, Farmarest, Oladín, Salamol, Salbutalan, Salbutamol, Salcomed, Tunxín, Unibrón, Ventolín.
Drug combinations
Albuterol and Dextromethorphan
Albuterol and Ipratropium
Chemistry
Albuterol: C~13~H~21~NO~3~. Mw: 239.31. (1) 1,3-Benzenedimethanol, α^1^-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-; (2) α^1^-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-α,α’-diol. CAS-18559-94-9 (1971).
Albuterol Sulfate: (C~13~H~21~NO~3~)~2~.H~2~SO~4~. Mw: 576.70. α1-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene – α,α’-diol sulfate (2:1). CAS-51022-70-9; CAS-18559-94-9 (1974).
Pharmacologic Category
Sympathomimetic (Adrenergic) Agents; Selective β~2~-Adrenergic Agonists. (ATC-Code: R03AC02).
Mechanism of action
Relaxes bronchial smooth muscle by action on β~2~-receptors.
Therapeutic use
Bronchodilator in reversible airway obstruction due to asthma or chronic obstructive pulmonary disease. Prevention of exercise-induced bronchospasm.
Pregnancy and lactiation implications
Maternal administration of oral or intravenous routes may produce tocolytic effects, fetal tachycardia and hypoglycemia. Safe use as an inhalation during pregnancy.
Unlabeled use
Tocolytic agent (injectable form).
Contraindications
Hypersensitivity to albuterol, adrenergic amines, or any component of the formulation. Tachyarrhythmias. Risk of abortion.
Warnings and precautions
Bronchospasm may occur (rare) with inhaled bronchodilating agents. Immediate hypersensitivity reactions (urticaria, angioedema, rash) have occurred. Not for use as a component of chronic asthma therapy without an anti-inflammatory agent. Elevation in blood pressure and heart rate. Arrhythmias. Use with caution in the following situations: cardiovascular disease (arrhythmia, hypertension or heart failure), diabetes mellitus (may increase serum glucose), glaucoma (may elevate intraocular pressure), hyperthyroidism (may stimulate thyroid activity), hypokalemia (may decrease serum potassium) and in seizure disorder (CNS stimulation/excitation). The use of oral systemic albuterol as a quick-relief medication and chronic use of inhaled β-agonists for long-term control of asthma is not recommended.