Hepatic injury (significant transaminase elevations, rare cases of hepatitis, fatty liver, decompensation of cirrhosis, and acute hepatic failure have occurred). Hypersensitivity reactions. Immune suppression (may increase risk of infection and may reactivate latent infection). Acute infusion reactions may occur. Lymphopenia (induces a decline in circulating T-lymphocytes (CD4^+^ and CD8^+^)). May increase risk of malignancies. Live vaccines should not be given concurrently.