Altretamine
- Atc Codes:L01XX03
- CAS Codes:645-05-6
- PHARMGKB ID:645-05-6
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
France: Hexastat; Germany: Hexalen; Sweden: Hexalen.
North America
Canada: Hexalen; USA: Hexalen.
Asia
Japan: Hexalen.
Drug combinations
Chemistry
Altretamine: C~9~H~18~N~6~. Mw: 210.28. (1) 1,3,5-Triazine-2,4,6-triamine, N,N,N’,N’,N»,N»-hexamethyl-; (2) Hexamethylmelamine. CAS-645-05-6 (1990).
Pharmacologic Category
Other Antineoplastic Agents. (ATC-Code: L01XX03).
Mechanism of action
Inhibits DNA and RNA synthesis.
Therapeutic use
Palliative treatment of ovarian cancer.
Pregnancy and lactiation implications
Teratogenic effects in animal studies. Not recommended during breast-feeding.
Unlabeled use
Contraindications
Hypersensitivity. Severe bone marrow suppression. Severe neurologic toxicity. Pregnancy.
Warnings and precautions
Hazardous agent. Bone marrow suppression is common (use with caution in patients previously treated with other myelosuppressive drugs). Neurotoxicity is common (use with caution in pre-existing neurotoxicity). Use with caution in hepatic or renal impairment.