Amlodipine
- Atc Codes:C08CA01
- CAS Codes:111470-99-6#88150-42-9
- PHARMGKB ID:111470-99-6#88150-42-9
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Norvasc; Belgium: Amlodipine, Amlogal, Amlor; Bulgaria: Accel, Agen, Alozur, Amilostad, Amlocor, Amlodigamma, Amlodipin, Amlodipine, Amlopin, Amloteron, Amlovask, Cardiovasc, Neodipin, Nordipin, Normodipine, Norvasc, Tenox; Cyprus: Afiten, Amdip, Amlorine, Amlotad, Norvasc; Czech Republic: Afiten, Agen, Alozur, Amilostad, Amlodigamma, Amlodipin, Amlodipine, Amlopp, Amloratio, Amlotenz, Amlozek, Apo-Amlo, Cardilopin, Genam, Hipres, Normodipine, Norvasc, Orcal, Recotens, Tensigal, Torella, Zeppeliton, Zorem, Zufalm; Denmark: Amlodipin, Norvasc; Estonia: Agen, Amlocard, Amlodigamma, Amlodipin, Amlodipine, Lofral, Normodipine, Normostad, Norvasc; Finland: Amlodipin, Amloratio, Norvasc; France: Amlodipine, Amlor; Germany: Amdina, Amlo, Amlobesilat, Amlobeta, Amlocard, Amloclair, Amlodicor, Amlodigamma, Amlodipin, Amlodoc, AmloLich, Amlosig, Amlospes, Amlotrina, Amparo, Dipi-Chris, Norvas, Norvasc; Greece: Amlibon Bes, Amlodil, Amlodin, Amlodipine, Amlopen, Amlopress, Amloretin, Amlosilat, Amodipan, Angioretic, Awadik, Axyplot, Baruden, Dafor, Evangio, Flodil, Karpin, Lavi-Press, Lodipin, Naxuril, Nordex, Norfan, Normodin, Norvagen, Norvalet, Norvasc, Pidolen, Precardin, Ramlet, Rovoxid, Vascodin, Zalmex; Hungary: Agen, Alozur, Amlipin, Amlobesyl, Amlodep, Amlodigamma, Amlodipin, Amlodipress, Amlodowin, Amlosante, Amlozek, Cardilopin, Normodipine, Norvasc, Sevikar, Tenox; Ireland: Amlid, Amlist, Amlode, Amlodipine, Amlotan; Italy: Abis, Almidis, Amlodipina, Amlopol, Antacal, Balarm, Krudipin, Losedin, Makadip, Monopina, Norvasc, Pressac, Zauris; Latvia: Agen, Amlocard, Amlodigamma, Amlodipin, Amlodipine, Lofral, Normodipine, Normostad, Norvasc, Tenox; Lithuania: Amlodipine; Luxembourg: Amlodipin, Amlodipine, Amlor; Malta: Amlo, Amlodipine, Baruden, Evangio, Istin, Lofral; Netherlands: Amlober, Amlodipine, Amlodno, Amlosyl, Norvasc; Poland: Amlodipine; Portugal: Amlodipina, Ibotec, Norvasc, Teufin, Tiflodipina, Vasoplus, Zabart; Romania: Agen, Almacor, Alozur, Amlo, Amlodigamma, Amlodipin, Amlodipina, Amlodipine, Amlohexal, Cardilopin, Eplodin, Norvasc, Norvatens, Stamlo, Tardip, Tenox, Vasorex; Slovakia: Accel, Agen, Alozur, Amilostad, Amlodigamma, Amlodipin, Amlopin, Cardilopin, Genam, Norvasc, Recotens, Tenox, Zamlodax; Slovenia: Amlodigamma, Amlodipin, Amlopin, Norvasc, Tenox; Spain: Amlodipino, Astudal, Norvas, Zabart; Sweden: Amlarrow, Amlobesyl, Amlodikon, Amlodipin, Amlodipine, Amlopin, Amlopress, Amloratio, Amlox, Ladipon, Norvasc; UK: Amlostin, Istin.
North America
Canada: Amlodipine, Norvasc; USA: Amlodipine, Norvasc.
Latin America
Argentina: Abloom, Amloc, Amlodine, Amlodipina, Amlotens, Amze, Anexa, Angiofilina, Angipec, Arteriosan, Calpres, Carboplex, Cardiorex, Cardivas, Coroval, Fabocef, Hipertensal, Ilduc, Mitokor, Nexotensil, Nikor, Pelmec, Pultex, Terloc, Tervalon, Zundic; Mexico: Aken, Amlibon, Avistar, Cropinex, Inivical, Nexus, Norpled, Norvas, Oralcam, Pequisy, Poltroon, Presone, Sistopres, Spinodin.
Asia
Japan: Amlodin, Amlodipine, Norvasc.
Drug combinations
Amlodipine and Aliskiren
Amlodipine and Atorvastatin
Amlodipine and Benazepril
Amlodipine and Lisinopril
Amlodipine and Olmesartan
Amlodipine and Perindopril Erbumine
Amlodipine and Telmisartan
Amlodipine and Valsartan
Amlodipine, Aliskiren and Hydrochlorothiazide
Amlodipine, Hydrochlorothiazide, and Olmesartan
Amlodipine, Hydrochlorothiazide, and Valsartan
Chemistry
Amlodipine Besylate: C~20~H~25~ClN~2~O~5~ C~6~H~6~O~3~S. Mw: 567.05. (1) 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (±)-, monobenzenesulfonate; (2) 3-Ethyl 5-methyl (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulfonate. CAS-111470-99-6; CAS-88150-42-9 (amlodipine)(1988).
Pharmacologic Category
Calcium-Channel Blocking Agents; Dihydropyridines. (ATC-Code: C08CA01).
Mechanism of action
Inhibits calcium ion from entering the voltage-sensitive channels of vascular smooth muscle and myocardium during depolarization, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation. Increases myocardial oxygen delivery in vasospastic angina.
Therapeutic use
Treatment of hypertension, symptomatic chronic stable angina, vasospastic (Prinzmetal’s) angina. Prevention of hospitalization due to angina with documented coronary artery disease.
Pregnancy and lactiation implications
Use in pregnancy only when clearly needed and when the benefits outweigh the potential hazard to the fetus. Administration is not recommended during lactation.
Unlabeled use
Contraindications
Hypersensitivity to amlodipine or any component of the formulation.
Warnings and precautions
Increased angina and/or myocardial infarction has occurred with initiation or dosage titration of calcium channel blockers. Symptomatic hypotension with or without syncope (rarely). Peripheral edema is common. Reflex tachycardia may occur. Caution in severe aortic stenosis, hepatic impairment, or in idiopathic hypertrophic subaortic stenosis.