Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Induces
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Standacillin; Belgium: Pentrexyl; Bulgaria: Ampicillin, Standacillin; Cyprus: Ampicillin, Pamecil, Penodil, Syntocil, Czech Republic: Ampicilin; Denmark: Ampicilin, Pentrexyl; Estonia: Ampicillin, Standacillin; Finland: A-Pen; France: Ampicilline; Germany: Ampicillin, Ampiciph, Ampisan, Ampisel, Ampitab, Apicin; Greece: Adelcopen, Ampenolet, Copercilex, Pentrexyl; Hungary: Axum, Semicillin, Standacillin, Unasyn; Ireland: Ampicillin, Clonamp, Rimacillin; Italy: Ampici, Ampilux, Amplital; Latvia: Ampicillin, Pamecil; Lithuania: Ampicillin; Netherlands: Ampicilline; Poland: Ampicillin; Portugal: Ampicilina, Hiperbiótico; Romania: Ampicilina, Ephicilin, Epicocillin, Pamecil, Standacillin; Slovakia: Ampicillin; Spain: Britapén, Gobemicina; Sweden: Doktacillin; UK: Penbritin.

North America

Canada: Apo-Ampi, Ampicillin; USA: Ampicillin, Principen.

Latin America

Argentina: Alpovex, Ampi-Bis, Ampicilina, Ampigen, Ampinox, Ampitenk, Bactilina, Fabopcilina, Galciclina, Histopen, Trifacilina; Brazil: Ambezetal, Ampi, Ampiciflan, Ampicil, Ampicilab, Ampicilase, Ampicilil, Ampicilina, Ampicilon, Ampigran, Ampilozin, Amplacilina, Amplacin, Amplibac, Binotal, Cilinon, Cilipen, Emicilin, Gramcilina, Neo Ampicilin; Mexico: Acilmed, Alphapen, Alvedrin, Am-An, Ambidrin, Ambiosol, Ampex, Ampicilina, Ampimex, Ampi-Quim, Ampi-Tecno, Amprexyn, Amsapen, Bestcilina, Binotal, Bremecina, Brupén, Dibacilina, Diferín, Expicín, Flamicina, Gramipén, Iqfacilina, Marovilina, Meprizina, Mibiot, Omnipen, Pebiot, Penbritin, Pentiver, Pentrexyl, Procilina, Prodifer, Sinaplín, Tronex, Zumorín.


Japan: Amipenix, Ampicillin, Solcillin, Viccillin.

Drug combinations

Ampicillin and Cloxacillin

Ampicillin and Diclofenac

Ampicillin and Floxacillin

Ampicillin and Guaifenesin

Ampicillin and Oxacillin

Ampicillin and Sulbactam


Ampicillin: C~16~H~19~N~3~O~4~S. Mw: 349.40. (1) 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, [2S-[2α,5α,6β(S*)]]-; (2)(2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. CAS-69-53-4; CAS-7177-48-2 (trihydrate)(1962).

Ampicillin Sodium: C~16~H~18~N~3~NaO~4~S. Mw: 371.39. 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-[2α,5α,6β(S*)]]-. CAS-69-52-3 (1966).

Pharmacologic Category

Antibacterials; Aminopenicillins. (ATC-Code: J01CA01; S01AA19).

Mechanism of action

Inhibits bacterial cell wall synthesis.

Therapeutic use

Treatment of susceptible bacterial infections (non-β-lactamase-producing organisms). Treatment or prophylaxis of infective endocarditis. Treatment of bacterial infections caused by streptococci, pneumococci, nonpenicillinase-producing staphylococci, Listeria, meningococci, strains of H. influenzae, Salmonella, Shigella, E. coli, Enterobacter, and Klebsiella.

Pregnancy and lactiation implications

For use in pregnant women for the management of premature rupture of membranes. Acceptable alternative to penicillin for the prevention of early-onset Group B Streptococcal disease in newborns. Use with caution if administered during lactation.

Unlabeled use


Hypersensitivity to ampicillin, any component of the formulation, or other penicillins.

Warnings and precautions

Hypersensitivity (anaphylactoid) reactions have been reported (especially with history of β-lactam hypersensitivity, history of sensitivity to multiple allergens, or previous IgE-mediated reactions). Use with caution in asthmatic patients. Rash may appear (it normally begins on the trunk and spreads over most of the body. It may be most intense at pressure areas, elbows, and knees). Fungal or bacterial superinfection (with prolonged use). Rash has developed during therapy in patients with infectious mononucleosis (ampicillin-class antibiotics not recommended in these patients). Use with caution in renal impairment.



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