Anastrozole
- Atc Codes:L02BG03
- CAS Codes:120511-73-1
- PHARMGKB ID:120511-73-1
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Anastro, Anastrodex, Anastrolan, Anastrozol, Arimidex; Belgium: Arimidex; Bulgaria: Anaromat, Anastrozole, Arimidex, Armotraz, Dispolan, Egistrozol, Ozolan, Zelotrin, Zynzol; Cyprus: Aremed, Arimidex; Czech Republic: Acydex, Alozex, Anabrest, Anaprex, Anasolde, Anastar, Anastrad, Anastrozol, Anastrozole, Anaya, Arimidex, Asnea, Betasolde, Deltasolde, Egistrozol, Epsisolde, Gammasolde, Mammozole, Mastoren, Oncofem, Trasolette, Zelotrin, Zynzol; Denmark: Arimidex; Estonia: Anastrozol, Anastrozole, Arimidex, Axastrol, Deltasolde, Episolde, Gammasolde, Mammozole, Trasolette, Zynzol; Finland: Anastrozol, Arimidex; France: Arimidex; Germany: Ana, Anastrozol, Arimidex, Chisolde, Deltasolde, Epsisolde, Etasolde, Gammasolde, Kappasolde, Lambdasolde, Mammozole, Mysolde, Omegasolde, Pisolde, Psisolde, Ribomidex, Sigmasolde, Thetasolde, Trasolette, Xisolde; Greece: Anastrozole, Ansyn, Arimidex, Astrazol, Enastros, Mysolde, Oxeda, Strazal, Viastrol, Zolitrat; Hungary: Anabrest, Anamataz, Anaromat, Anastrozol, Anastrozole, Arilla, Arimidex, Axastrol, Dakorec, Deltasolde, Epsisolde, Gammasolde, Mammozole, Mastoren, Nobrec, Ozolan, Trasolette, Valmidex, Zolitrat, Zynzol; Ireland: Amidex, Anastrozole, Arimidex; Italy: Arimidex; Latvia: Anastrozol, Anastrozole, Arimidex, Axastrol, Deltasolde, Egistrozol, Epsisolde, Gammasolde, Mammozole, Trasolette, Zynzol; Lithuania: Anastrozole; Luxembourg: Arimidex; Malta: Anastrozole, Aremed, Arimidex; Netherlands: Anastrozol, Arimidex, Barstra, Biostrol, Egistrozol, Genstra, Kirana, Mastrol, Strakir, Zolkir, Zolzyn; Poland: Acydex, Anastelb, Anastralan, AnastroGen, AnastroLek, Anastrozol, Anastrozole, Ansyn, Arimidex, Arinel, Atrozol, Betasolde, Detasolde, Egistrozol, Epsisolde, Gammasolde, Mammozole, Mamostrol, Ozolan, Symanastrol, Zeltorin, Zolastrol; Portugal: Anacyne, Anastrozol, Arimidex, Remidex; Romania: Anaromat, Anastelb, Anastraze, Anastrozol, Anastrozole, Arimidex, Egistrozol, Eloza, Enzamidex, Ozolan; Slovakia: Anaprex, Anastelb, Anastrozol, Anastrozole, Ansyn, Arimidex, Asnea, Deltasolde, Egistrozol, Epsisolde, Gammasolde, Mammozole, Mastoren, Ozolan, Trasolette, Zelotrin, Zynzol; Spain: Anabrest, Arimidex; Sweden: Anastelb, Anastrozol, Anastrozole, Arimidex, Mimastran; UK: Arimidex.
North America
Canada: Arimidex; USA: Arimidex.
Latin America
Argentina: Anaskebir, Anastraze, Anastrozol, Anebol, Arimidex, Aromenal, Cefer, Distalene, Gondonar, Leprofen, Pantestone-Filaxis, Puricap, Trozolite; Brazil: Anastrozol, Arimidex; Mexico: Arimidex.
Asia
Japan: Arimidex.
Drug combinations
Chemistry
Anastrozole: C~17~H~19~N~5~. Mw: 293.37. (1) 1,3-Benzenediacetonitrile, α,α,α’,α’-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-; (2) α,α,α’,α’-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile. CAS-120511-73-1 (1995).
Pharmacologic Category
Antineoplastic Agents; Endocrine Therapy. Aromatase Inhibitor. (ATC-Code: L02BG03).
Mechanism of action
Inhibits aromatase, thus preventing the conversion of androstenedione to estrone, and of testosterone to estradiol.
Therapeutic use
Treatment of locally-advanced or metastatic breast cancer in postmenopausal women. Treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy. Adjuvant treatment of early estrogen receptor-positive breast cancer in postmenopausal women.
Pregnancy and lactiation implications
Fetotoxicity was observed in animal studies. Exclude pregnancy before initiating. Use with caution during lactation.
Unlabeled use
Contraindications
Hypersensitivity to anastrozole or any component of the formulation. Pregnancy.
Warnings and precautions
Hazardous agent. May cause decreases in bone mineral density. Use with caution in hyperlipidemias (total cholesterol and LDL-cholesterol increase). Exclude pregnancy before initiating.