Antithrombin III
- Atc Codes:B01AB02
- CAS Codes:52014-67-2
- PHARMGKB ID:52014-67-2
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Antithrombin III, Atenativ, Kybernin; Belgium: Concentre d’Antithrombine III; Bulgaria: Antithrombin III; Czech Republic: Anbinex, Antithrombin III, Atenativ, Atryn, Kybernin; Denmark: Antithrombin III, Atenativ, Atryn; Estonia: Atryn; Finland: Atenativ; France: Aclotine; Germany: Anbinex, AT III, Atenativ, Atryn, Kybernin; Greece: Kibernyn; Hungary: Antithrombin III; Italy: Aclotine; Latvia: Atryn; Lithuania: Atryn; Luxembourg: Kybernin; Malta: Antithrombin III; Netherlands: Atenativ, Antitrombine III, Atryn; Poland: Anbinex, Antithrombin III, Atenativ, Atryn, Kibernyn; Portugal: Atenativ, Atryn, Anbinex, Antitrombin III, Kybernin; Romania: Atryn, Kybernin; Slovakia: Anbinex, Antithrombin III, Atenativ, Atryn, Kybernin; Slovenia: Kybernin; Spain: Anbinex, Atenativ, Kibernyn; Sweden: Antithrombin III, Atenativ, Atryn; UK: Atryn.
North America
Canada: Antithrombin III, Thrombate III; USA: Atryn.
Latin America
Argentina: Antitrombina III; Brazil: Kybernin; Mexico: Atend, Octati.
Asia
Japan: Anthrobin, Neuart, Nonthron.
Drug combinations
Chemistry
Antithrombin III Human: The glycoprotein antithrombin obtained from human plasma. CAS-52014-67-2.
Pharmacologic Category
Antithrombotic Agents; Anticoagulants, Miscellaneous. (ATC-Code: B01AB02).
Mechanism of action
α~2~-Globulin. Inactivates thrombin, plasmin, and other active serine proteases of coagulation, including factors IXa, Xa, XIa, and XIIa.
Therapeutic use
Treatment of hereditary antithrombin III deficiency.
Pregnancy and lactiation implications
Teratogenic effects were not observed in animal studies. There are no adequate and well-controlled studies in pregnant women. Use caution during lactation.
Unlabeled use
Acquired antithrombin III deficiencies related to disseminated intravascular coagulation.
Contraindications
Hypersensitivity to any component of the formulation.
Warnings and precautions
Product of human plasma (may potentially contain infectious agents).