Antithrombin III

Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Antithrombin III, Atenativ, Kybernin; Belgium: Concentre d’Antithrombine III; Bulgaria: Antithrombin III; Czech Republic: Anbinex, Antithrombin III, Atenativ, Atryn, Kybernin; Denmark: Antithrombin III, Atenativ, Atryn; Estonia: Atryn; Finland: Atenativ; France: Aclotine; Germany: Anbinex, AT III, Atenativ, Atryn, Kybernin; Greece: Kibernyn; Hungary: Antithrombin III; Italy: Aclotine; Latvia: Atryn; Lithuania: Atryn; Luxembourg: Kybernin; Malta: Antithrombin III; Netherlands: Atenativ, Antitrombine III, Atryn; Poland: Anbinex, Antithrombin III, Atenativ, Atryn, Kibernyn; Portugal: Atenativ, Atryn, Anbinex, Antitrombin III, Kybernin; Romania: Atryn, Kybernin; Slovakia: Anbinex, Antithrombin III, Atenativ, Atryn, Kybernin; Slovenia: Kybernin; Spain: Anbinex, Atenativ, Kibernyn; Sweden: Antithrombin III, Atenativ, Atryn; UK: Atryn.

North America

Canada: Antithrombin III, Thrombate III; USA: Atryn.

Latin America

Argentina: Antitrombina III; Brazil: Kybernin; Mexico: Atend, Octati.


Japan: Anthrobin, Neuart, Nonthron.

Drug combinations


Antithrombin III Human: The glycoprotein antithrombin obtained from human plasma. CAS-52014-67-2.

Pharmacologic Category

Antithrombotic Agents; Anticoagulants, Miscellaneous. (ATC-Code: B01AB02).

Mechanism of action

α~2~-Globulin. Inactivates thrombin, plasmin, and other active serine proteases of coagulation, including factors IXa, Xa, XIa, and XIIa.

Therapeutic use

Treatment of hereditary antithrombin III deficiency.

Pregnancy and lactiation implications

Teratogenic effects were not observed in animal studies. There are no adequate and well-controlled studies in pregnant women. Use caution during lactation.

Unlabeled use

Acquired antithrombin III deficiencies related to disseminated intravascular coagulation.


Hypersensitivity to any component of the formulation.

Warnings and precautions

Product of human plasma (may potentially contain infectious agents).



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