Armodafinil
- Atc Codes:N06BA
- CAS Codes:112111-43-0
- PHARMGKB ID:112111-43-0
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Substrate of
- Inhibits
- Induces
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Nuvigil.
Drug combinations
Chemistry
Armodafinil: C~15~H~15~NO~2~S. Mw: 273.35. (1) Acetamide, 2-[(diphenylmethyl)sulfinyl]-, (-)-; (2)(-)-2-[(R)-(Diphenylmethyl)sulfinyl]acetamide. CAS-112111-43-0 (2004).
Pharmacologic Category
Anorexigenic Agents and Respiratory and Cerebral Stimulants, Miscellaneous. (ATC-Code: N06BA).
Mechanism of action
Binds to the dopamine transporter and inhibits dopamine reuptake, which may result in increased extracellular dopamine levels in the brain.
Therapeutic use
Improve wakefulness in excessive daytime sleepiness associated with narcolepsy and shift work sleep disorder. Adjunctive therapy for obstructive sleep apnea/hypopnea syndrome.
Pregnancy and lactiation implications
Use with caution during pregnancy and lactation.
Unlabeled use
Contraindications
Hypersensitivity to armodafinil, modafinil, or any component of the formulation.
Warnings and precautions
Risk of serious and life-threatening rashes with modafinil (Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug rash with eosinophilia and systemic symptoms). Risk of multiorgan hypersensitivity reactions (with modafinil) and angioedema and anaphylactoid reactions (with armodafinil). Use not recommended in left ventricular hypertrophy or mitral valve prolapse syndrome. Use caution in history of myocardial infarction, angina, or hypertension. Use with caution in hepatic impairment. Use caution in history of psychosis, depression, or mania (modafinil might worsen symptoms). Use with caution in Tourette’s syndrome (may unmask tics). Potential for drug dependency exists.