Aspirin (Acetylsalicylic Acid)

Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Substrate of
  • Inhibits
  • Induces
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Acekapton, Aspiricor, Aspirin, Aspro, CorProtect, Herz ASS, Herzschutz ASS, Thrombo ASS, Thrombostad, Togal Mono, Tromalyt ASS Retard; Belgium: Acenterine, ASA, Asaflow, Aspegic, Aspirine, Cardegic, Cardioaspirine, Cardiphar, Dispril, Sedergine; Bulgaria: Acetylin, Acetysal, Anopyrin, Aspegic, Aspetin, Aspirin, Keptan, Thrombo ASS, Trombogard, Unirex; Cyprus: Aspirem, Aspirin, Aspro Clear, Disprin, Nu-Seals, Salospir; Czech Republic: Acylpyrin, Anopyrin, Aspirin, Godasal, Kardegic; Denmark: Aspirin, Hjerdyl, Hjertemagnyl, Magnyl; Estonia: Acidum Acetylsalicylicum, ASA, Aspirin, Asprovit, Herzass, Thrombo Ass; Finland: ASA, Aspirin, Disperin, Primaspan, Thrombo ASA; France: Acide Acetylsalicylique, Aspirine, Aspirisucre, Aspro; Germany: Acesal, Acetylsalicylsäure, Andolor N, Apernyl mit Acetylsalicylsäure, ASA Atid, Aspirin, Aspro, ASS, Avensis, Gepodan, Godamed, Hermasalin, Miniasal, Pyracyl N, Sanocapt, Sonopain, Thrombo-Solpyron, Usambramed N; Greece: Acetylsalicylic Acid, Asacard, Aspirin, Bufferin, Dispril, New Asper, Salospir; Hungary: ASA, Aspirin, Aspro C, Astrix, Kardegic; Ireland: Asacard, Aspirin, Caprin, Disprin, Nu-Seals; Italy: Ac Acsal, Aspirina, Aspirinetta, Aspro, Cardioaspirin; Latvia: Acetilsalicilskābe, Alka-Prim, ASA, Aspecardum, Aspirin, HerzASS, Thrombo ASS; Lithuania: Acetylsalicylic Acid; Malta: Aspegic, Aspirin, Aspro Clear, Maximum Strength, Nu-Seals; Netherlands: Acetylsalicylzuur, Asacard, Aspirine, Aspro, Togal; Poland: Acard, Acesan, Ampiryna, Anopyrin, ASA, Asaltec, Aspirin, Aspotabs, Aspro, Bestpirin, Cardiopirin, Encopirin, Entreik, Miraspryn, Nipas, Novasen, Novaspryn, Polocard, Polopiryna, Proficar, Rhonal, Salpirin, Tomapyrin Comfort, Upsarin; Portugal: A-A-S, Ácido Acetilsalicílico, Actipiril, Asacard, ASP, Aspirina, Cartia, Migraspirina, Toldex Retard, Tromalyt; Romania: Acesil, Acid Acetilsalicilic, Asaprin, Aspenter, Aspimax, Aspirin, Europirin, Ozopirin T, Rompirin E, Thrombo ASS; Slovakia: Acylpyrin, Anopyrin, Aspirin; Slovenia: Andol, Aspirin, Cardiopirin; Spain: A.A.S., Adiro, Aspirina, Bioplak, Rhonal, Sedergine, Tromalyt; Sweden: Acetylsalicylsyra, Acetyratio, Albyl Minor, Asacard, Aspirin, Bamyl, Magnecyl, Trombyl; UK: Aspirin, Caprin, Nu-Seals.

North America

Canada: Acetylsalicylic Acid, ASA, Asadol, Asaphen, Asatab, Aspergum, Aspirin, Bufferin, Entrophen, Lowprin, Novasen, Rivasa; USA: Ascriptin, Aspercin, Aspergum, Aspirin, Aspirtab, Bufferin, Buffinol, Easprin, Ecotrin, Genacote, Halfprin, Zorprin.

Latin America

Argentina: A.A.S., Aspirina, Aspirinetas, Bayaspirina, Cardioaspirina, Desenfriolito, Ecotrin, Geniol SC sin cafeina, Lafeaspirina, Nuevapina, Vipirina Ginsex Corazón; Brazil: A.A.S, Ácido Acetilsalicílico, Analgesin, Aspirina, Bufferin, Cardio AAS, Cimaas, Salicil, Salicin, Salitil, Somalgin;

Mexico: Acetil-A, Ácido Acetilsalicílico, Acitab, Antacsal, ASA, Aspirina Protect, Doloquim, Midolen, Vastecel.


Japan: Acetyl Salicylic Acid, Aspirin, Bayaspirin, Nichiaspirin, Salitison, Zenaspirin.

Drug combinations

Aspirin and Acetaminophen

Aspirin and Ascorbic Acid (Vitamin C)

Aspirin and Caffeine

Aspirin and Carisoprodol

Aspirin and Cilostazol

Aspirin and Clopidogrel

Aspirin and Codeine

Aspirin and Dipyridamole

Aspirin and Magnesium Oxide

Aspirin and Methocarbamol

Aspirin and Metoclopramide

Aspirin and Oxycodone

Aspirin and Pentazocine

Aspirin and Pravastatin

Aspirin, Acetaminophen, and Caffeine

Aspirin, Acetaminophen, and Codeine

Aspirin, Ascorbic Acid (Vitamin C), and Caffeine

Aspirin, Ascorbic Acid (Vitamin C), and Codeine

Aspirin, Ascorbic Acid (Vitamin C), and Troxerutin

Aspirin, Ascorbic Acid (Vitamin C), Tocopherol (Vitamin E)

Aspirin, Butalbital, and Caffeine

Aspirin, Caffeine, and Chlorpheniramine

Aspirin, Caffeine, and Dihydrocodeine

Aspirin, Caffeine, and Orphenadrine

Aspirin, Caffeine, and Quinine

Aspirin, Carisoprodol, and Codeine

Aspirin, Chlorpheniramine, and Phenylephrine

Aspirin, Diphenylpyraline, and Metamfepramone

Aspirin, Lithium, and Quinine

Aspirin, Ascorbic Acid (Vitamin C), Caffeine, and Guaifenesin

Aspirin, Acetaminophen, Aluminum Hydroxide, Caffeine, and Magnesium Hydroxide

Aspirin, Aluminum Hydroxide, Ascorbic Acid, Caffeine, Chlorpheniramine, and Magnesium Carbonate

Other Aspirin combinations: Sodium Bicarbonate


Aspirin: C~9~H~8~O~4~. Mw: 180.16. (1) Benzoic acid, 2-(acetyloxy)-; (2) Salicylic acid acetate. CAS-50-78-2.

Pharmacologic Category

Platelet-aggregation Inhibitors. Thrombolytic Agents. Nonsteroidal Anti-inflammatory Agents; Salicylates. (ATC-Code: A01AD05; B01AC06; N02BA01; N02BA01).

Mechanism of action

Inhibits prostaglandin synthesis. Acts on the hypothalamus heat-regulating center to reduce fever. Blocks prostaglandin synthetase action, which prevents formation of the platelet-aggregating substance thromboxane A~2.~

Therapeutic use

Treatment of pain, inflammation, fever. Prophylaxis of myocardial infarction, stroke or transient ischemic episodes. Rheumatoid arthritis, rheumatic fever, osteoarthritis, and gout, revascularization procedures (coronary artery bypass graft, percutaneous transluminal coronary angioplasty, carotid endarterectomy), stent implantation.

Pregnancy and lactiation implications

Salicylates cross the placenta and enter fetal circulation. In general, low doses during pregnancy needed for the treatment of certain medical conditions have not been shown to cause fetal harm, however, discontinuing therapy prior to delivery is recommended. Use of safer agents for routine management of pain or headache should be considered. Use with caution while breast-feeding.

Unlabeled use

Prevention of pre-eclampsia, complications associated with autoimmune disorders (lupus or antiphospholipid syndrome).


Hypersensitivity to salicylates, other NSAIDs, or any component of the formulation. Asthma. Rhinitis. Nasal polyps. Inherited or acquired bleeding disorders (including factor VII and factor IX deficiency). Avoid use in children (<16 years of age) for viral infections (chickenpox or flu symptoms), with or without fever, due to a potential association with Reye’s syndrome. Pregnancy (third trimester especially).

Warnings and precautions

Risk of salicylate sensitivity. Discontinue use if tinnitus or impaired hearing occurs. Use with caution in platelet and bleeding disorders, in dehydration, in erosive gastritis or peptic ulcer disease or in renal impairment. Avoid use in severe renal and hepatic impairment. Avoid ethanol (can increase bleeding risks). Children and teenagers who have or are recovering from chickenpox or flu-like symptoms should not use this product (risk of developing Reye’s syndrome). Should be avoided in surgical patients for 1-2 weeks prior to surgery (to reduce the risk of excessive bleeding).



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