Use with caution in pediatric patients (may be an increased risk of suicidal ideation). Aggressive behavior (particularly with the initiation of therapy). Allergic reactions (angioneurotic edema, urticaria, and rash) may occur. Risk of cardiovascular events in patients with serious cardiac problems. Rarely, severe hepatotoxicity may develop (use with caution in hepatic impairment and in poor metabolizers of CYP2D6-metabolized drugs). Priapism might occur (rarely). Does not worsen anxiety in existing anxiety disorders or tics related to Tourette’s disorder. Use with caution in hypertension and other cardiovascular conditions that might be exacerbated by increases in blood pressure or heart rate. Use caution in history of psychotic illness or bipolar disorder (may induce mixed/manic disorder or psychotic symptoms). Atomoxetine is not approved for major depressive disorder. Use cautiously in history of urinary retention or bladder outlet obstruction (may cause urinary retention/hesitancy).