Baclofen
- Atc Codes:M03BX01
- CAS Codes:1134-47-0
- PHARMGKB ID:1134-47-0
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Lioresal; Belgium: Baclofen, Lioresal; Bulgaria: Baclofen; Cyprus: Lioresal; Czech Republic: Baclofen, Lioresal; Denmark: Baklofen, Lioresal; Finland: Baklofen, Lioresal; France: Baclofene, Lioresal; Germany: Baclofen, Lebic, Lioresal; Greece: Glasbor, Jofen, Lioresal, Miorel, Vioridon; Hungary: Baclofen, Lioresal; Ireland: Baclopar, Lioresal; Italy: Lioresal; Latvia: Baclosal; Lithuania: Baclosal; Luxembourg: Baclofen, Lioresal; Netherlands: Baclofen, Lioresal; Poland: Baclofen, Lioresal; Portugal: Lioresal; Slovakia: Baclofen; Spain: Lioresal; Sweden: Baklofen, Lioresal; UK: Baclofen, Lioresal, Lyflex.
North America
Canada: Baclofen, Lioresal, Nu-Baclo; USA: Baclofen, Gablofen, Kemstro, Lioresal.
Latin America
Argentina: Baclofeno, Bafen, Lioresal; Brazil: Baclofen, Baclon, Lioresal.
Asia
Japan: Gabalon, Lioresal.
Drug combinations
Chemistry
Baclofen: C~10~H~12~ClNO~2~. Mw: 213.66. (1) Butanoic acid, 4-amino-3-(4-chlorophenyl)-; (2) β-(Aminomethyl)-p-chlorohydrocinnamic acid. CAS-1134-47-0 (1971).
Pharmacologic Category
GABA-derivative Skeletal Muscle Relaxants. (ATC-Code: M03BX01).
Mechanism of action
Inhibits the transmission of mono/polysynaptic reflexes at the spinal cord level, possibly by hyperpolarization of primary afferent fiber terminals.
Therapeutic use
Treatment of spasticity associated with spinal cord lesions.
Pregnancy and lactiation implications
Crosses placenta. Enters breast milk (small amounts). Compatible with breast-feeding.
Unlabeled use
Bladder spasticity, cerebral palsy, intractable hiccups, intractable pain relief, trigeminal neuralgia, Huntington’s chorea.
Contraindications
Hypersensitivity to baclofen or any component of the formulation.
Warnings and precautions
Withdrawal reactions may occur with abrupt discontinuation, particularly severe with intrathecal use (hyperpyrexia, obtundation, rebound/exaggerated spasticity, muscle rigidity, and rhabdomyolysis), leading to organ failure and fatalities. Risk of CNS depression. Caution in history of seizure disorder. Caution in renal disorders.