Beclomethasone
- Atc Codes:A07EA07
- CAS Codes:5534-09-8#4419-39-0
- PHARMGKB ID:5534-09-8#4419-39-0
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Becotide, Beklomet Easyhaler; Belgium: Beclometasone, Beclophar, Beconase, Becotide, Clipper, Ecobec, Qvar; Bulgaria: Aldecin, Becotide; Cyprus: Becloforte, Beconase, Becotide, Clenil, Viarex; Czech Republic: Becloforte, Beclomet, Becodisks, Beconase, Becotide, Clenil, Ecobec, Nasobec; Denmark: Aerobec, Beclomet Easyhaler, Beconase, Becotide; Estonia: Beconase, Becotide; Finland: Aerobec, Beclomet Easyhaler, Beclonasal, Beconase; France: Asmabec Clickhaler, Beclometasone, Beclone, Beclospin, Beconase, Becotide, Bemedrex, Ecobec, Miflasone, Prolair, Qvar, Rhinomaxil; Germany: Aerobec, Beclo, Beclomet, Beclometason, Beclorhinol, Beconase, Junik, Ratioallerg, Rhinivict, Sanasthmax, Sanasthmyl, Ventolair; Greece: Beclomet, Becloneb, Beclospin, Becolex, Becotide, Bidiclin, Breathline, Clenil, Dermolate, Irionozol, Qvar, Respocort, Rinosol, Sotaderm; Hungary: Aldecin, Ecobec; Ireland: Asmabec, Beclazone, Beclomethasone, Becloneb, Beclospin, Beconase, Becotide, Beklomet, Clenyl, Nasobec, Qvar; Italy: Becotide, Bemedrex, Clenil, Clenilexx, Clipper, Klostenal, Menaderm, Prontinal, Topster; Latvia: Becloforte, Beconase, Becotide; Luxembourg: Beclometason, Beclometatop, Beconase, Becotide, Beklomet, Qvar; Netherlands: Beclodin, Beclometason, Beconase, Becotide, Qvar; Poland: Beclazone, Beclocort, Beconase, Becotide, Nasobec; Portugal: Beclometasona, Beclotaide, Beconase, Becotide, Direspin, Ecobec, Qvar; Slovakia: Beclomet, Ecobec, Nasobec; Spain: Beclo, Beclosona, Bidiclín, Clipper, Dereme, Menaderm; Sweden: Aerobec, Beclomet, Becotide; UK: Aerobec, Asmabec, Becalzone, Becloforte, Beclometasone, Beclomethasone, Becodisks, Beconase, Becotide, Clenil, Clipper, Filair, Nasobec, Propaderm.
North America
Canada: Beclo, Beclomethasone, Propaderm, Qvar, Rivanase; USA: Beconase, Qvar.
Latin America
Argentina: Propavent, Rinosol; Brazil: Alerfin-Farmalab, Beclort, Beclosol, Clenil, Miflasona; Mexico: Beclazone, Beclometasona, Beconase, Becotide, Dobipro, Riferina.
Asia
Japan: Albezon, Aldecin, Alroyer, Beclacin, Beclazone, Beclomethasone, Becloze, Bectmiran, Espetat, Ipe, Mily, Nanadora, Nicepie, Penbulin, Propaderm, Qvar, Salcoat, Taunus.
Drug combinations
Beclomethasone and Formoterol
Chemistry
Beclomethasone Dipropionate: C~28~H~37~ClO~7~. Mw: 521.04. (1) Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11β,16β)-; (2) 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate. CAS-5534-09-8; CAS-4419-39-0 (beclomethasone)(1973).
Pharmacologic Category
Respiratory Tract Agents; Anti-inflammatory Agents; Corticosteroids. Hormones and Synthetic Substitutes; Adrenals. (ATC-Code: A07EA07).
Mechanism of action
Controls the rate of protein synthesis. Depresses the migration of polymorphonuclear leukocytes and fibroblasts. Reverses capillary permeability and lysosomal stabilization at the cellular level to prevent or control inflammation.
Therapeutic use
Maintenance and prophylactic treatment of asthma. Symptomatic treatment of seasonal or perennial rhinitis. Prevention of recurrence of nasal polyps following surgery.
Pregnancy and lactiation implications
Inhaled corticosteroids are recommended for the treatment of asthma and allergic rhinitis during pregnancy. Use cautiously during lactation.
Unlabeled use
Gastrointestinal inflammation.
Contraindications
Hypersensitivity to beclomethasone or any component of the formulation. Status asthmaticus (not to use for relief of acute bronchospasm).
Warnings and precautions
May cause hypercorticism or suppression of hypothalamic-pituitary-adrenal axis, leading on occasions to adrenal crisis. Withdrawal and discontinuation should be done slowly and carefully. May cause bronchospasm with wheezing after inhalation. Prolonged use may increase the incidence of secondary infection, mask acute infection (including fungal infections), prolong or exacerbate viral infections, or limit response to vaccines due to immunosuppression. Exposure to chickenpox should be avoided. Should not be used to treat ocular herpes simplex or cerebral malaria. Restrict use in active tuberculosis. Prolonged treatment has been associated with the development of Kaposi’s sarcoma. May cause psychiatric disturbances, including depression, euphoria, insomnia, mood swings, personality changes, and exacerbate pre-existing psychiatric conditions. Not to be used in status asthmaticus or for the relief of acute bronchospasm. Long-term use has been associated with fluid retention (caution in hepatic and renal impairment) and hypertension (caution in renal impairment). May alter glucose production/regulation leading to hyperglycemia (caution in diabetes mellitus). Risk of gastrointestinal perforation (caution in diverticulitis, peptic ulcer, ulcerative colitis). Exacerbation of myasthenia gravis symptoms has occurred especially during initial treatment with corticosteroids. Myocardial rupture may occur (caution following acute myocardial infarct). Seizures reported with adrenal crisis. Metabolic clearance varies with thyroid status (increases in hyperthyroidism and decreases in hypothyroidism).