Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Inhibits
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Czech Republic: Babydent; Denmark: Dolodent; Finland: Otisyn; France: Activox, Lysocalmspray, Prothyl, Topex; Germany: Anaesthesin; Hungary: Babydent; Ireland: Burneze Spray, Lanacane; Italy: Gengivarium; Luxembourg: Hurricaine; Poland: Baby Orajel, Dentispray, Dermopur, Etylu Aminobenzoesan, Orajel; Portugal: Dentispray, Topigel; Slovakia: Babydent; Spain: Benzocaína, Dentispray, Gartricin, Hurricaine, Lanacane, Nani Pre Dental, Nani-Predental, Topispray; UK: AAA Mouth and Throat Spray, BurnEze Spray, Tyrozets.

North America

Canada: Anbesol Baby, Zilactin-B; USA: Americaine, Anbesol, Benzodent, Bi-Zets, Boil-Ease, Chiggerex, Chiggertox, Cylex, Dent’s Extra Strength Toothache, Dentapaine, Detane, Foille, HDA Toothache, Hurricaine, Ivy-Rid, Kanka-A Soft Brush, Lanacane, Little Teethers, Mycinettes, Orabase with Benzocaine, Orajel PM, Oticaine, Otocaine, Outgro, Red Cross Canker Sore, Rid-A-Pain Dental, Sepasoothe, Skeeter Stik, Sting-Kill, Tanac, Thorets, Trocaine, Zilactin-B.

Latin America

Argentina: Cabuchi; Brazil: Solarcaine; Mexico: Auralyt, Gomas Garde B, Graneodin B.

Drug combinations

Benzocaine and Cetylpyridinium

Benzocaine and Tetracaine

Benzocaine, Ephedrine, and Phenazone

Other Benzocaine combinations: Dexpanthenol; Magnesium Oxide; Pantothenic Acid (Vitamin B~5~); Retinol (Vitamin A)


Benzocaine: C~9~H~11~NO~2~. Mw: 165.19. (1) Benzoic acid, 4-amino-, ethyl ester; (2) Ethyl p-aminobenzoate. CAS-94-09-7.

Pharmacologic Category

EENT Preparations; Local Anesthetics. Antipruritics and Local Anesthetics (Topical). (ATC-Code: C05AD03; D04AB04; N01BA05; R02AD01).

Mechanism of action

Ester local anesthetic decreases the neuronal membrane’s permeability to sodium ions and so inhibits depolarization, blocking both initiation and conduction of nerve impulses.

Therapeutic use

Temporary relief of pain associated with pruritic dermatosis, pruritus, minor burns, bee stings, and insect bites, mouth and gum irritations (toothache, minor sore throat pain, canker sores, dentures, orthodontia, teething, mucositis, stomatitis). Sunburn. Hemorrhoids. Anesthetic lubricant for passage of catheters and endoscopic tubes.

Pregnancy and lactiation implications

Reproduction studies have not been conducted. Use cautiously during pregnancy and lactation.

Unlabeled use


Hypersensitivity to benzocaine, other ester-type local anesthetics, or any component of the formulation. Secondary bacterial infection of area. Ophthalmic use.

Warnings and precautions

Methemoglobinemia may occur following topical use, particularly with higher concentration spray formulations applied to the mouth or mucous membranes (caution with breathing problems, inflamed/damaged mucosa, heart disease, children <6 months of age, and hemoglobin or enzyme abnormalities (glucose-6-phosphodiesterase deficiency, hemoglobin-M disease, NADH-methemoglobin reductase deficiency, pyruvate-kinase deficiency)). Do not use on open wounds.



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