Benzonatate

Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Inhibits
  • Drug Interactions
  • Dosage
  • Special Considerations

Brand Names

North America

Canada: Tessalon; USA: Tessalon.

Latin America

Mexico: Beknol, Benzonal, Benzonatato, Capsicof, D-Tato, Lemtosid, Nafatosín, Novapsyl, Pebegal, Pharben, Supracof, Tesalón, Tesopén, Texovén, Tuzzil.

Drug combinations

Chemistry

Benzonatate: C~30~H~53~NO~11~. Mw: approx. 603.00. (1) Benzoic acid, 4-(butylamino)-, 2,5,8,11,14,17,20,23,26-nonaoxaoctacos-28-yl ester; (2) 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl p-(butylamino)benzoate. CAS-104-31-4.

Pharmacologic Category

Antitussives. (ATC-Code: R05DB01).

Mechanism of action

Suppresses cough by topical anesthetic action on the respiratory stretch receptors.

Therapeutic use

Symptomatic relief of nonproductive cough.

Pregnancy and lactiation implications

Use with caution during pregnancy or lactation.

Unlabeled use

Contraindications

Hypersensitivity to benzonatate, related compounds (such as tetracaine), or any component of the formulation.

Warnings and precautions

Release of benzonatate in the mouth can cause a temporary local anesthesia of the oral mucosa and difficulty swallowing. May produce changes in CNS, such as drowsiness, impaired coordination, blurred vision, increased anxiety, dizziness, sedation, tremor, agitation. May produce upset stomach or nausea. May produce numbness in chest or feeling of chill.

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