Recommended only for obese patients with a body mass index ≥30 kg/m^2^, or ≥27 kg/m^2^ in the presence of other risk factors such as hypertension, diabetes, and/or dyslipidemia or a high waist circumference. Not approved for long-term use (may lead to dependency). Amphetamines may impair the ability to engage in potentially hazardous activities. A rare, frequently fatal disease of the lungs (primary pulmonary hypertension) has been described with increased frequency in patients receiving some anorexigens. The use of some anorexigens has been associated with the development of valvular heart disease (avoid stimulants in serious structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, or other serious cardiac problems that could increase the risk of sudden death). Caution in diabetes mellitus (antidiabetic agent requirements may be altered with anorexigens and concomitant dietary restrictions). Caution in hypertension and other cardiovascular conditions that might be exacerbated by increases in blood pressure or heart rate. Caution in history of seizure disorders. Caution in Tourette’s syndrome (stimulants may unmask tics). Not recommended for use in patients who have used other anorectic agents within the past year.