Brotizolam
- Atc Codes:N05CD09
- CAS Codes:57801-81-7
- PHARMGKB ID:57801-81-7
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Substrate of
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Special Considerations
Brand Names
Europe
Austria: Lendorm; Belgium: Lendormin; Germany: Lendorm, Lendormin; Greece: Lendormin; Hungary: Lendormin; Italy: Lendormin; Luxembourg: Lendormin; Netherlands: Lendormin; Portugal: Lendormin; Spain: Sintonal.
Latin America
Mexico: Lindormiín.
Asia
Japan: Amnezon, Brozom, Brotizolam, Brometon, Cinberamin, Eurimolan, Godmin, Lendem, Lendormin, Nestrom, Ronfleman, Zestromin.
Drug combinations
Chemistry
Brotizolam: C~15~H~10~BrClN~4~S. Mw: 393.69. (1) 2-Bromo-4-(O-chlorophenyl)-9-methyl-6H-thieno[3,2-f]-S-triazolo[4,3-a][1,4]diazepine; (2) 6H-Thieno[3,2,f][1,2,4]triazolo[4,3,a][1,a]diazepine, 2-bromo-4-(2-chlorophenyl)-9-methyl-. CAS-57801-81-7 (1983).
Pharmacologic Category
Anxiolytics, Sedatives, and Hypnotics; Benzodiazepines, Short Term. (ATC-Code: N05CD09).
Mechanism of action
Binds specifically to benzodiazepinic receptors in the CNS. Reduces the sleep induction period and the frequency of waking, and prolongs sleeping period.
Therapeutic use
Insomnia.
Pregnancy and lactiation implications
Benzodiazepines have been widely used in pregnant patients. In some infants use of benzodiazepines in the third trimester and during labor seems to be associated with neonatal withdrawal symptoms or floppy infant syndrome. Slow development in the early years has been reported following in utero exposure to benzodiazepines, but by 4 years of age most developed normally. An increased risk of oral cleft after in utero exposure has been described. Anxiolytic drugs are excreted in breast milk and could conceivably alter CNS functions in the infant both in the short and long term. Not recommended during lactation.
Unlabeled use
Contraindications
Hypersensitivity to brotizolam o other benzodiazepines. Myasthenia gravis. Severe respiratory depression. Sleep apnea. Severe hepatic impairment.
Warnings and precautions
High risk of developing dependence after regular use of benzodiazepines, even in therapeutic doses for short periods. Dependence is particularly likely in patients with history of alcohol or drug abuse and in those with marked personality disorders. The mechanism of dependence is unclear but may involve reduced γ-aminobutyric acid (GABA) activity resulting from down-regulation of GABA receptors. Adjuvant therapy should generally be avoided. Most benzodiazepines can adversely affect parameters of driving performance in healthy subjects. Anterograde amnesia is more common with short-acting drugs such as triazolam.