Calcium Citrate

Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage

Brand Names


Germany: Calcitrat; Hungary: Citrokalcium.

Latin America

Argentina: Calcimax, Calcio Cit Simple, Calcional Citrato, Sigmacal; Brazil: Miocalven; Mexico: Calcival.

Drug combinations

Calcium Citrate and Alendronate

Other Calcium Citrate combinations: Ascorbic Acid (Vitamin C); Calcium Chloride; Calcium Gluconate; Calcium Lactate; Calcium Phosphate; Cholecalciferol (Vitamin D~3~); Copper Sulfate; Dextrose; Magnesium Citrate; Magnesium Chloride; Manganese; Potassium Chloride; Potassium Citrate; Pyridoxine (Vitamin B~6~); Sodium Acetate; Sodium Borate; Sodium Chloride; Sodium Citrate; Tocopherol (Vitamin E); Zinc Oxide


Calcium Citrate: C~12~H~10~Ca~3~O~14~ 4H~2~O. Mw: 570.49. 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, calcium salt (2:3), tetrahydrate. CAS-5785-44-4.

Pharmacologic Category

Replacement Preparations. Phosphate-removing Agents. Antidotes. Calcium Salts. (ATC-Code: A12AA).

Mechanism of action

Calcium moderates nerve and muscle performance via action potential excitation threshold regulation. Calcium citrate combines with dietary phosphate to form insoluble calcium phosphate which is excreted in feces and reduces phosphate absorption.

Therapeutic use

Antacid. Calcium deficiency or hyperphosphatemia (e.g. osteoporosis, osteomalacia, mild/moderate renal insufficiency, hypoparathyroidism, postmenopausal osteoporosis, rickets). Dietary supplement.

Pregnancy and lactiation implications

Unlabeled use


Hypersensitivity to any component of the formulation. Hypercalcemia. Renal calculi. Ventricular fibrillation.

Warnings and precautions

Constipation, bloating, and gas are common with calcium supplements (especially carbonate salt). Calcium absorption is impaired in achlorhydria (common in the elderly). Hypercalcemia and hypercalciuria are most likely to occur in hypoparathyroid patients receiving high doses of vitamin D. Use caution when administering calcium supplements to patients with history of kidney stones or renal failure. Calcium administration interferes with absorption of some minerals and drugs. It is recommended to administer vitamin D concomitantly for optimal calcium absorption. Taking calcium (≤500 mg) with food improves absorption.



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