Calcium Glubionate

Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Belgium: Sandoz Calcium; Denmark: Calcium-Sandoz; France: Calcium Alko; Sweden: Calcium-Sandoz.

Drug combinations


Calcium Glubionate: C~18~H~32~CaO~19~ H~2~O. Mw: 610.53. (1) Calcium, (4-O-β-D-galactopyranosyl-D-gluconato-O^1^)(D-gluconato-O^1^)-, monohydrate; (2)(D-Gluconato)(lactobionato)calcium monohydrate; (3) Calcium D-gluconate lactobionate monohydrate. CAS-12569-38-9; CAS-31959-85-0 (anhydrous)(1970).

Pharmacologic Category

Replacement Preparations. Phosphate-removing Agents. Antidotes. Calcium Salts. (ATC-Code: A12AA02).

Mechanism of action

As dietary supplement, used to prevent or treat negative calcium balance.

Therapeutic use

Dietary supplement. Calcium deficiency. Osteoporosis.

Pregnancy and lactiation implications

Unlabeled use


Hypersensitivity to any component of the formulation. Renal calculi.

Warnings and precautions

Constipation, bloating, and gas are common with calcium supplements (especially carbonate salt). Calcium absorption is impaired in achlorhydria (common in the elderly). Hypercalcemia and hypercalciuria are most likely to occur in hypoparathyroid patients receiving high doses of vitamin D. Use caution when administering calcium supplements to patients with history of kidney stones. Calcium administration interferes with absorption of some minerals and drugs. It is recommended to administer vitamin D concomitantly for optimal calcium absorption. Taking calcium (≤500 mg) with food improves absorption. May produce decreased serum magnesium determinations.



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