Calcium Gluconate
- Atc Codes:A12AA03#D11AX03
- CAS Codes:299-28-5#526-95-4
- PHARMGKB ID:299-28-5#526-95-4
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Calciumgluconat; Cyprus: Calcium Gluconate; France: Gluconate de Calcium B Braun; Germany: Calciumgluconat; Hungary: Calcimusc; Latvia: Calcii gluconas; Poland: Calcium Gluconicum; UK: Calcium Gluconate.
North America
USA: Cal-G, Cal-GLU.
Latin America
Argentina: Gluconato de Calcio.
Asia
Japan: Calcicol.
Drug combinations
Calcium Gluconate: Ascorbic Acid (Vitamin C); Boric Acid; Calcium Chloride; Calcium Citrate; Calcium Lactate; Calcium Lactobionate; Ergocalciferol (Vitamin D~2~); Iron (II) Gluconate; Magnesium Acetate; Magnesium Chloride; Saccharomyces cerevisiae; Sorbitol
Chemistry
Calcium Gluconate: C~12~H~22~CaO~14~. Mw: 430.37. D-Gluconic acid, calcium salt (2:1). CAS-299-28-5 (anhydrous); CAS-526-95-4 (D-gluconic acid).
Pharmacologic Category
Replacement Preparations. Phosphate-removing Agents. Antidotes. Calcium Salts. (ATC-Code: A12AA03; D11AX03).
Mechanism of action
Calcium moderates nerve and muscle performance via action potential excitation threshold regulation. It helps to prevent or decrease the rate of bone loss.
Therapeutic use
Hypocalcemia. Tetany, cardiac disturbances of hyperkalemia, cardiac resuscitation when epinephrine fails to improve myocardial contractions, hypocalcemia. Calcium supplementation.
Pregnancy and lactiation implications
Reproduction studies not completed. Enters breast milk. Endogenous calcium is excreted in breast milk.
Unlabeled use
Calcium channel blocker overdose. Hydrofluoric acid burns.
Contraindications
Hypersensitivity to calcium gluconate or any component of the formulation. Ventricular fibrillation during cardiac resuscitation. Digitalis toxicity or suspected digoxin toxicity. Hypercalcemia.
Warnings and precautions
May produce cardiac arrest. Constipation, bloating, and gas are common with oral calcium supplements (especially carbonate salt). Use with caution in the following cases: digitalized patients (hypercalcemia may precipitate cardiac arrhythmias), respiratory acidosis, renal impairment, or respiratory failure (acidifying effect of calcium chloride may potentiate acidosis), severe hyperphosphatemia. Use caution when administering calcium supplements to patients with history of kidney stones or renal failure. Calcium administration interferes with absorption of some minerals and drugs. It is recommended to administer vitamin D concomitantly for optimal calcium absorption. Taking oral calcium (≤500 mg) with food improves absorption. Solutions may contain aluminum (risk of toxicity following prolonged administration in premature neonates or renal impairment). May produce increased serum calcium determinations. May produce decreased serum magnesium determinations.