Calfactant
- Atc Codes:R07AA30
- CAS Codes:183325-78-2
- PHARMGKB ID:183325-78-2
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Special Considerations
Brand Names
North America
USA: Infasurf.
Drug combinations
Chemistry
Calfactant: An unmodified calf lung lavage extract containing mostly phospholipids and surfactant-specific proteins (SP-B and SP-C). CAS-183325-78-2 (1997).
Pharmacologic Category
Pulmonary Surfactants. (ATC-Code: R07AA30).
Mechanism of action
Replaces deficient or ineffective endogenous lung surfactant in neonates with respiratory distress syndrome (RDS) or in neonates at risk of developing RDS, preventing the alveoli from collapsing during expiration (endogenous lung surfactant modifies alveolar surface tension, stabilizing the alveoli).
Therapeutic use
Prevention and treatment of respiratory distress syndrome in premature infants.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Warnings and precautions
May cause transient episodes of bradycardia, decreased oxygen saturation, endotracheal tube blockage or reflux of calfactant into endotracheal tube. For intratracheal administration only. Rapidly affects oxygenation and lung compliance.