Capsaicin
- Atc Codes:M02AB01#N01BX04
- CAS Codes:404-86-4
- PHARMGKB ID:404-86-4
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Induces
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Austria: Hansaplast Wärme, Qutenza; Czech Republic: Capsicolle, Qutenza; Estonia: Qutenza; Finland: Qutenza; Germany: Hansaplast Wärme, Qutenza; Greece: Arthralgon, Capser, Gelcen, Sensocaps, Zacin; Hungary: Hansaterm, Nicoflex; Ireland: Axsain, Qutenza, Zacin; Latvia: Qutenza; Lithuania: Qutenza; Portugal: Hansaplast Emplastro Térmico, Hansaterm, Neodor, Qutenza; Romania: Qutenza; Lithuania: Qutenza; Spain: Alacapsin, Capsicin, Capsidol, Hansaterm, Picasum, Sensedol; Sweden: Capsina, Qutenza; UK: Axsain, Zacin.
North America
Canada: Nature Works Swedish Bitters Capsaicin Cream, Zoderm; USA: Qutenza.
Latin America
Mexico: Capsidol.
Drug combinations
Chemistry
Capsaicin: C~18~H~27~NO~3~. Mw: 305.41. 6-Nonenamide, (E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl. CAS-404-86-4.
Pharmacologic Category
Skin and Mucous Membrane Agents; Local Anesthetics, Topical. (ATC-Code: M02AB01; N01BX04).
Mechanism of action
Induces release of substance P (main chemomediator of pain impulses from the periphery) from peripheral sensory neurons, depleting the neuron of substance P (after repeated stimulation), and prevents reaccumulation.
Therapeutic use
Pain associated with postherpetic neuralgia, rheumatoid arthritis, osteoarthritis, diabetic neuropathy. Postsurgical pain.
Pregnancy and lactiation implications
Unlabeled use
Pain associated with psoriasis, chronic neuralgias unresponsive to other forms of therapy, and intractable pruritus.
Contraindications
Hypersensitivity to capsaicin or any component of the formulation.
Warnings and precautions
For external use only. Should not be applied to broken or irritated skin. The affected area should not be tightly bandaged or exposed to direct sunlight or a heat lamp.