Benzodiazepines have been associated with anterograde amnesia. May cause CNS depression (caution in patients receiving other CNS depressants or psychoactive medication). Effects with other sedative drugs or ethanol may be potentiated. Parenteral administration should be avoided in comatose patients or shock. Paradoxical reactions, including hyperactive or aggressive behavior, reported with benzodiazepines, particularly in adolescent/pediatric or psychiatric patients. Caution in depression, particularly if suicidal risk. Potential for drug dependency. Tolerance, psychological and physical dependence may occur with prolonged use. Use with caution in hepatic/renal impairment, impaired gag reflux, porphyria, respiratory disease, debilitated patients, and in the elderly (benzodiazepines have been associated with falls and traumatic injury). Use with extreme caution in patients who are at risk of falls and in children. Rebound or withdrawal symptoms may occur following abrupt discontinuation or large decreases in dose.