Choline Magnesium Trisalicylate
- Atc Codes:N02BA
- CAS Codes:2016-36-6#18917-95-8#18917-89-0
- PHARMGKB ID:2016-36-6#18917-95-8#18917-89-0
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Trilisate.
Drug combinations
Chemistry
Choline Salicylate: C~12~H~19~NO~4~. Mw: 241.28. (2-Hydroxyethyl)trimethylammonium salicylate. CAS-2016-36-6 (1988).
Magnesium Salicylate: C~14~H~10~MgO~6~ 4H~2~O. Mw: 370.59. (1) Magnesium, bis(2-hydroxybenzoato-O1,O2)-, tetrahydrate; (2) Magnesium salicylate (1:2), tetrahydrate. CAS-18917-95-8; CAS-18917-89-0 (anhydrous).
Pharmacologic Category
Analgesics and Antipyretics; Nonsteroidal Anti-inflammatory Agents; Salicylates. (ATC-Code: N02BA).
Mechanism of action
Weakly inhibits cyclooxygenase enzymes, resulting in decreased formation of prostaglandin precursors. Antipyretic, analgesic, and anti-inflammatory properties.
Therapeutic use
Osteoarthritis, rheumatoid arthritis, and other arthritis. Acute painful shoulder. Mild to moderate pain. Fever.
Pregnancy and lactiation implications
Animal reproduction studies not conducted. Due to the known effects of other salicylates (closure of ductus arteriosus), use during late pregnancy should be avoided. Enters breast milk (use caution).
Unlabeled use
Contraindications
Hypersensitivity to salicylates, other nonacetylated salicylates, other NSAIDs, or any component of the formulation. Bleeding disorders. Pregnancy (3^rd^ trimester).
Warnings and precautions
Tinnitus or impaired hearing may indicate toxicity. Use with caution in the following cases: asthma, dehydration, erosive gastritis or peptic ulcer, hepatic/renal impairment, and in the elderly (may develop asymptomatic peptic ulceration and/or hemorrhage). Salicylate salts may not inhibit platelet aggregation (should not be substituted for aspirin in the prophylaxis of thrombosis). Children and teenagers who have or are recovering from chickenpox or flu-like symptoms should not use this product; changes in behavior (along with nausea and vomiting) may be an early sign of Reye’s syndrome.