Benzodiazepines have been associated with anterograde amnesia. May cause CNS depression. Use with caution in patients receiving other CNS depressants or psychoactive medication (may potentiate effects with other sedative drugs or ethanol; concurrent use with valproic acid may result in absence status). May cause paradoxical reactions, including hyperactive or aggressive behavior, mainly in adolescent/pediatric or psychiatric patients. Use with caution in history of drug abuse or acute alcoholism. Tolerance, psychological and physical dependence may occur with prolonged use. Does not have analgesic, antidepressant, or antipsychotic properties. Worsening of seizures may occur when added to patients with multiple seizure types. Use with caution in hepatic/renal impairment. Use with caution in impaired gag reflux/respiratory disease. Use with caution in debilitated patients. Use with caution in the elderly (benzodiazepines have been associated with falls and traumatic injury). Rebound or withdrawal symptoms may occur following abrupt discontinuation or large decreases in dose (caution when reducing dose or withdrawing therapy). Flumazenil may cause withdrawal in patients receiving long-term benzodiazepine therapy.