Collagen Hemostat

Table of contents

  • Brand Names
  • Drug Combinations
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Dosage
  • Pharmacokinetics and Pharmacodynamics

Brand Names

North America

USA: Avitene, Helistat, Helitene, Instat MCH.

Drug combinations

Collagen, Aprotinin, Fibrinogen, and Thrombin


Pharmacologic Category

Skin and Mucous Membrane Agents, Miscellaneous, Hemostatic Agent. (ATC-Code: B02BC07).

Mechanism of action

Collagen hemostat is an absorbable topical hemostatic agent prepared from purified bovine corium collagen and shredded into fibrils. In contact with a bleeding surface, collagen hemostat attracts platelets which adhere to its fibrils and undergo the release phenomenon. This triggers aggregation of the platelets into thrombi in the interstices of the fibrous mass, initiating the formation of a physiologic platelet plug.

Therapeutic use

Adjunct to hemostasis when control of bleeding by ligature is ineffective or impractical.

Pregnancy and lactiation implications

Unlabeled use


Hypersensitivity to any component of the formulation. Products of bovine origin. Closure of skin incisions, contaminated wounds. Application to bone surfaces to which prosthetic materials are attached with methylmethacrylate adhesives.

Warnings and precautions

Pain, numbness, or paralysis reported if used near a bony or neural space and left inside patient. Not intended for treatment of systemic coagulation disorders. Not for use when origin of bleeding is unknown.



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