Collagenase is an enzyme derived from the fermentation of Clostridium histolyticum capable of specifically hydrolyzing peptide bonds of undenatured and denatured collagen. Collagenase liquefies necrotic tissue without damaging collagen in healthy tissue or newly formed granulation tissue. In addition, it does not act on fat, fibrin, keratin, or muscle. Contributes towards the formation of granulation tissue and subsequent epithelization of dermal ulcers and severely burned areas. May remove substrates necessary for bacterial proliferation or may permit antibodies, leukocytes, and antibiotics better access to the infected area.