Corticorelin
- Atc Codes:V04CD04
- CAS Codes:121249-14-7
- PHARMGKB ID:121249-14-7
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: CRH Ferring; France: STIMU-ACTH; Germany: Cortirel, CRH Ferring; Netherlands: CRH Ferring.
North America
USA: Acthrel.
Asia
Japan: hCRH.
Drug combinations
Chemistry
Corticorelin Ovine Triflutate: C~205~H~339~N~59~O~63~S xC~2~HF~3~O~2~. Corticotropin-releasing factor (sheep), trifluoroacetate. CAS-121249-14-7 (1990).
Pharmacologic Category
Diagnostic Agent; Pituitary Function. (ATC-Code: V04CD04).
Mechanism of action
Stimulates ACTH release from anterior pituitary (stimulates the adrenal cortex to produce cortisol).
Therapeutic use
Diagnostic test used in ACTH-dependent Cushing’s syndrome to differentiate between pituitary and ectopic production of ACTH.
Pregnancy and lactiation implications
Reproduction studies not conducted. Excretion in breast milk unknown (use caution).
Unlabeled use
Contraindications
Hypersensitivity to corticorelin or any component of the formulation.
Warnings and precautions
Use of heparin to maintain I.V. patency is not recommended (risk of hypotension). Use with caution in previous reactions to sheep products (lanolin). Doses administered as a bolus or in excess of recommendations have been associated with asystole, chest tightness, dyspnea, hypotension, loss of consciousness, and transient tachycardia (infusion over 30 seconds may reduce the potential for these effects). False negative responses may occur in 5% to 10% of patients.