Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: CRH Ferring; France: STIMU-ACTH; Germany: Cortirel, CRH Ferring; Netherlands: CRH Ferring.

North America

USA: Acthrel.


Japan: hCRH.

Drug combinations


Corticorelin Ovine Triflutate: C~205~H~339~N~59~O~63~S xC~2~HF~3~O~2~. Corticotropin-releasing factor (sheep), trifluoroacetate. CAS-121249-14-7 (1990).

Pharmacologic Category

Diagnostic Agent; Pituitary Function. (ATC-Code: V04CD04).

Mechanism of action

Stimulates ACTH release from anterior pituitary (stimulates the adrenal cortex to produce cortisol).

Therapeutic use

Diagnostic test used in ACTH-dependent Cushing’s syndrome to differentiate between pituitary and ectopic production of ACTH.

Pregnancy and lactiation implications

Reproduction studies not conducted. Excretion in breast milk unknown (use caution).

Unlabeled use


Hypersensitivity to corticorelin or any component of the formulation.

Warnings and precautions

Use of heparin to maintain I.V. patency is not recommended (risk of hypotension). Use with caution in previous reactions to sheep products (lanolin). Doses administered as a bolus or in excess of recommendations have been associated with asystole, chest tightness, dyspnea, hypotension, loss of consciousness, and transient tachycardia (infusion over 30 seconds may reduce the potential for these effects). False negative responses may occur in 5% to 10% of patients.



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